ABPath Chemical Pathology
Chemical Pathology
More study resources
Cheat sheet
Keep the key ideas within reach.
ExploreKey terms
Get comfortable with the vocabulary.
ExploreStudy plan
Give each week a clear focus.
ExploreCommon mistakes
Understand the traps and how to avoid them.
ExploreCase studies
Put your knowledge to work in context.
ExploreExam-day guide
Prepare for the day ahead.
ExploreAbout this exam
Chemical Pathology is an American Board of Pathology subspecialty certification for pathologists who want to demonstrate advanced knowledge in laboratory medicine, including the analytic, interpretive, and consultative aspects of clinical chemistry. The examination is a one-day, computer-based test that blends written and practical questions in each section; the practical portion presents graphs, charts, formulas, diagrams, tables, or other images rather than specimen images alone. According to the ABPath exam description, the exam contains 270 questions and allows 6 hours and 18 minutes, and every question is multiple-choice in the one-best-answer format. Content spans laboratory administration, specimen collection, units and measurement, calculations and statistics, quality control, instrumentation, analytic methods, metabolic and electrolyte disorders, proteins and hemoglobin, coagulation, and broader clinical laboratory evaluation including point-of-care testing, serology, toxicology, and consultation. Candidates should prepare by building fluency in quantitative problem solving, since formulas and calculations appear in practical items, and by reviewing each subject area systematically rather than concentrating only on clinical chemistry topics. This page is an independent study resource and is not affiliated with or endorsed by ABPath; candidates should confirm all exam logistics directly with the board.
What you'll study
About ABPath Chemical Pathology preparation
What is the Chemical Pathology exam format?
It is a one-day, computer-based examination made up of combined Written and Practical questions in each section. All questions are multiple-choice in the one-best-answer format, and the practical portion uses graphs, charts, formulas, diagrams, tables, or other images.
How many questions and how much time?
The ABPath exam description lists 270 questions and a total time of 6 hours and 18 minutes. Because written and practical items are mixed within each section, plan your pacing across the whole day rather than assuming a separate practical block.
Do I have to pass the written and practical parts separately?
Yes. Per ABPath, a candidate must pass both the written and the practical portions of the examination in the same administration in order to pass the examination. A strong performance on one portion does not compensate for a failing performance on the other.
What topics does the exam cover?
ABPath lists subject areas including laboratory administration and management, patient preparation and specimen collection, standards and units of measurement, calculations and statistics, quality control, instrumentation, analytic methods, disorders of metabolism, electrolyte and acid/base disorders, serum protein and hemoglobin abnormalities, coagulation and hemostasis, and clinical laboratory evaluation of organ and systemic diseases, reproduction and newborn screening, point-of-care testing, infectious disease serology and immune disorders, toxicology and therapeutic drug monitoring, and patient care decision-making and consultation.
How difficult is the exam?
ABPath states the questions measure both a body of knowledge and problem-solving ability, so recall alone is insufficient. The practical items with formulas, tables, and charts reward candidates who can apply concepts quickly. Difficulty is subjective, but quantitative reasoning and quality-control interpretation are common pressure points.
What is the most common way candidates underprepare?
Two recurring mistakes are treating the exam as pure clinical chemistry and neglecting management, statistics, and quality control, and practicing calculation-free review. Because practical questions include formulas and tables, work through quantitative problems under time pressure rather than only reading about them.
In what order should I study?
Start with the analytic foundation: units, calculations and statistics, quality control, and instrumentation, since these skills recur inside clinical items. Then move through method-based topics into organ-system and disorder content, finishing with consultation, toxicology, and point-of-care testing. Reserve time for timed mixed-topic practice.
How do I apply, and what does it cost?
Application procedures, deadlines, and fees are set by ABPath and are not published on this page. Consult the ABPath subspecialty exam dates, deadlines, and fees page and the Booklet of Information, and apply through the board's PATHway system. This site is independent and not affiliated with ABPath.
If I fail, can I retake the exam?
Retake eligibility and any limits are governed by ABPath policies, which are not detailed on this page. Review the Unsuccessful Candidates and Booklet of Information sections on the ABPath site for the current rules before planning a repeat attempt.