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Sudden painless vision loss in a 68-year-old with a crowded disc

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Sudden painless vision loss in a 68-year-old with a crowded disc

A 68-year-old man presents to your practice at 9 am reporting sudden painless loss of the upper half of his vision in the right eye, noticed on waking. He has hypertension treated with amlodipine and a 20-pack-year smoking history. Entering visual acuity is 6/18 OD and 6/6 OS. Confrontation shows an inferior altitudinal field defect OD. Pupils: no relative afferent defect, but the right pupil reacts sluggishly. Fundoscopy OD shows a swollen, hyperaemic optic disc with blurred margins and a small splinter haemorrhage at the disc edge; the left disc is small, crowded, with no cupping and a cup-to-disc ratio of 0.1. IOP is 16 mmHg in both eyes. He has no headache, jaw claudication, or scalp tenderness. Your next patient is waiting and you have 20 minutes before your schedule backs up.

1. What is your leading diagnosis, and what features in this presentation support it over the main alternatives?

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The leading diagnosis is non-arteritic anterior ischaemic optic neuropathy (NAION).

Supporting features:

  • Altitudinal field loss - classic for NAION; the field defect typically respects the horizontal midline.
  • Sectoral disc swelling with splinter haemorrhage - ischaemic disc oedema rather than the diffuse oedema of papillitis.
  • Crowded fellow disc (cup-to-disc 0.1, no cupping) - a small scleral canal is the strongest anatomical risk factor for NAION.
  • Vascular risk profile - age, hypertension, smoking.
  • No pain on eye movement - argues against optic neuritis, which also usually affects younger patients and produces a marked relative afferent pupillary defect.

Alternatives to exclude:

  • Giant cell arteritis (AION): no headache, jaw claudication, or scalp tenderness, but age over 50 means you cannot dismiss it on history alone. It must be actively excluded - see next task.
  • Central retinal artery occlusion: would show a cherry-red spot and retinal pallor, not disc swelling.
  • Vitreous or retinal detachment: no floaters, no retinal findings described.
  • Optic neuritis: wrong demographic, usually painful, and typically has a clear RAPD. The sluggish pupil here is consistent with unilateral optic nerve dysfunction but the absent RAPD is unusual and worth rechecking with a neutral-density filter.

Key point for the exam: NAION is a diagnosis of pattern recognition plus exclusion of GCA. You cannot stop at NAION without addressing GCA.

2. How do you manage the GCA question in the next 20 minutes, and what would change your plan?

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Immediate priority: exclude GCA before the patient leaves.

  1. Targeted history - ask specifically about jaw claudication, scalp tenderness, temporal headache, shoulder/hip girdle stiffness (polymyalgia rheumatica), fever, weight loss, and transient visual obscurations. A negative history lowers but does not eliminate probability.
  2. Examination - palpate the temporal arteries for tenderness, nodularity, and reduced pulse; check for scalp tenderness.
  3. Inflammatory markers today - arrange same-day ESR and CRP. In GCA, ESR is typically markedly elevated, though a normal ESR does not fully exclude it.
  4. Referral - urgent same-day ophthalmology or medical review for temporal artery biopsy and consideration of high-dose corticosteroids if suspicion is meaningful. Do not start steroids yourself without a plan for biopsy timing, because steroids can render the biopsy non-diagnostic within days.

What would change the plan:

  • Any positive GCA feature, or markedly raised ESR/CRP → treat as GCA until proven otherwise: same-day referral, do not wait, and counsel the patient that the fellow eye is at risk.
  • Strongly negative history and normal markers → proceed with NAION management but still refer non-urgently for confirmation and cardiovascular workup.

NAION management regardless:

  • Explain that vision loss is usually stable and that there is no proven treatment that restores vision.
  • Critical counselling point: the fellow eye is at risk (roughly 15–20% over five years).
  • Refer to the GP for aggressive vascular risk factor control - blood pressure, lipids, smoking cessation, and diabetes screening.
  • Consider low-dose aspirin after medical advice.
  • Document the crowded disc in the fellow eye and arrange review.

3. The patient asks whether his vision will come back and whether the other eye is at risk. How do you counsel him, and what documentation and follow-up do you put in place?

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Counselling - be honest and specific:

  • Vision loss from NAION is usually permanent; a minority improve slightly, but he should not expect recovery. Some patients notice improvement as the disc swelling settles, but this is modest.
  • The other eye is at risk - quoted figures are roughly 15–20% over five years, higher in the first year. This is why vascular risk factor control matters.
  • The fellow disc is crowded, which is the anatomical reason for the risk; this is not something that can be surgically corrected.
  • Warning symptoms: if he develops sudden vision loss in the left eye, he should seek urgent care the same day.
  • Reassure on the GCA question - explain why you are checking inflammatory markers and what to do if he develops headache, jaw pain, or scalp tenderness.

Documentation:

  • Presenting acuity, field defect, pupil findings, disc appearance in both eyes, IOP, and the negative GCA screen.
  • The counselling given, including the fellow-eye risk figure and warning symptoms.
  • Referrals made and their urgency.

Follow-up plan:

  • Review in 4–6 weeks to confirm disc swelling is resolving (swelling that persists or worsens should prompt reconsideration of the diagnosis).
  • GP letter requesting blood pressure, lipid, glucose, and smoking-cessation management.
  • Advise he continues driving only if he meets the local visual standards; document the field defect and advise he reports it to the licensing authority if required.
  • Repeat visual fields at review to establish a baseline.