Anatomy, Physiology and Microbiology
Anatomy, Physiology and Microbiology
This domain tests basic structure and function plus microbiology applied to infection control. Expect normal values, organ facts and sterilisation questions.
Core rules
- Cardiac output = heart rate × stroke volume; normal about 5 L/min.
- Blood values: haemoglobin 12–16 g/dL in women and 13–17 g/dL in men; white cells 4000–11,000/µL; platelets 150,000–450,000/µL.
- The right lung has three lobes and the left has two; surfactant is secreted by type II pneumocytes.
- The nephron filters about 125 mL/min; most reabsorption occurs in the proximal convoluted tubule.
- Gram stain: gram-positive organisms stain purple, gram-negative pink.
- Sterilisation kills spores - autoclave at 121 °C, 15 psi for 15–20 minutes. Disinfection does not kill spores.
Worked example
Heart rate 75/min and stroke volume 70 mL. Cardiac output = 75 × 70 = 5250 mL/min = 5.25 L/min. State the unit clearly; mixing litres and millilitres is a common error.
Traps
- Left lung has two lobes, not three.
- Sterilisation versus disinfection is a frequent distinction.
- Platelets form the plug in primary haemostasis; clotting factors come later in the cascade.