Valvular heart disease
Questions test severity thresholds, the timing of intervention and the distinction between primary and secondary valve disease. Numerical thresholds matter.
Aortic stenosis
- Severe: peak velocity 4 m/s or more, mean gradient 40 mmHg or more, valve area 1.0 cm2 or less (0.6 cm2/m2 or less).
- Symptoms (angina, syncope, dyspnoea) in severe AS are an indication for aortic valve replacement; asymptomatic severe AS is not automatically an indication.
- Low-flow low-gradient AS with reduced EF requires dobutamine stress echocardiography or CT calcium scoring.
- TAVR for high or prohibitive surgical risk and increasingly for intermediate risk; SAVR for younger low-risk patients.
Regurgitation and stenosis
- Aortic regurgitation: wide pulse pressure, decrescendo diastolic murmur, Austin Flint murmur. Surgery for symptoms or ejection fraction 50% or less, or LV end-systolic diameter 50 mm or more.
- Mitral stenosis: rheumatic, loud S1, opening snap, diastolic rumble. Percutaneous balloon valvotomy when morphology is suitable and there is no left atrial thrombus or moderate mitral regurgitation.
- Mitral regurgitation: primary (leaflet or chordal) versus secondary (ventricular). Surgery for symptomatic severe primary MR, or EF 60% or less, or end-systolic diameter 40 mm or more. Secondary MR: optimise guideline therapy first, consider transcatheter edge-to-edge repair.
Endocarditis
- Modified Duke criteria; three blood culture sets before antibiotics; TTE then TOE.
- Prophylaxis only for prosthetic valves, prior endocarditis, unrepaired cyanotic congenital disease and repaired lesions with residual defects or prosthetic material.
Worked example
A 78-year-old with syncope, mean gradient 48 mmHg, valve area 0.7 cm2 and preserved EF has symptomatic severe AS and should be referred for valve replacement after heart team assessment.
Traps
- Waiting for symptoms in severe AS, or operating on asymptomatic severe AS without other triggers.
- Confusing primary and secondary MR when planning surgery.
- Offering antibiotic prophylaxis for isolated bicuspid valve or mitral valve prolapse.