ABP Pediatric Hematology-Oncology study plan

Classify anemias by MCV and reticulocyte index, and state the first three discriminating labs for each category

Differentiate iron deficiency from thalassemia trait using iron studies and red cell indices without looking at notes

Distinguish the mechanisms and typical lab patterns of G6PD deficiency, hereditary spherocytosis, autoimmune hemolysis, and anemia of inflammation

Explain the physiologic basis of physiologic anemia of infancy and the neonatal nadir

Compare sickle cell disease and beta-thalassemia major across genetics, chronic labs, and organ complications

Outline acute sickle cell management for vaso-occlusive crisis, acute chest syndrome, and stroke risk

Distinguish Fanconi anemia, Diamond-Blackfan anemia, congenital dyskeratosis, and acquired aplastic anemia by presentation and diagnostic testing

Select appropriate iron chelation strategy given ferritin and organ iron burden

Separate primary from secondary hemostasis defects using bleeding pattern, platelet count, PT, PTT, and von Willebrand studies

Differentiate immune thrombocytopenia, thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, and inherited platelet disorders

Describe diagnostic and treatment pathways for hemophilia A and B including inhibitor development

Calculate factor replacement dosing for a bleed and for perioperative coverage

Select anticoagulant agent and duration for pediatric venous thromboembolism in provoked, unprovoked, and catheter-associated settings

State which patients warrant inherited thrombophilia testing and which do not

Identify indications, contraindications, and monitoring parameters for unfractionated heparin, low-molecular-weight heparin, and direct oral anticoagulants in children

List the initial diagnostic steps for a child with suspected acute leukemia

Compare B-cell acute lymphoblastic leukemia and acute myeloid leukemia by morphology, immunophenotype, cytogenetics, and risk stratification

Explain induction, consolidation, maintenance, and central nervous system prophylaxis phases and their toxicities

Manage tumor lysis syndrome and febrile neutropenia using risk-based pathways

Interpret minimal residual disease results and state their prognostic implications

Differentiate Hodgkin lymphoma from the major pediatric non-Hodgkin lymphoma subtypes by presentation, immunophenotype, and staging

Compare neuroblastoma, Wilms tumor, osteosarcoma, medulloblastoma, and retinoblastoma by age at presentation, staging, and core treatment

Recognize and initiate management of superior vena cava syndrome, spinal cord compression, and hyperleukocytosis

Map late effects of alkylator, anthracycline, and radiation exposure to the surveillance organ system

Select appropriate blood component and dose for anemia, thrombocytopenia, and coagulopathy in pediatric and neonatal patients

Recognize and manage acute hemolytic, febrile non-hemolytic, allergic, and transfusion-related acute lung injury reactions

State indications for irradiated, leukoreduced, washed, and cytomegalovirus-safe products

Compare autologous, matched sibling, and unrelated donor hematopoietic stem cell transplantation by indication, graft source, and major complications including graft-versus-host disease

Apply supportive care measures for mucositis, pain, nausea, and infection prophylaxis in the immunocompromised child

Discuss survivorship care planning, fertility preservation, and neurocognitive late effects with families

Apply palliative care principles and a framework for ethical conflicts including assent, confidentiality, and resource allocation

Integrate all five domains in timed, mixed-topic practice