AACN ACNPC-AG study materials
AACN ACNPC-AG study resources

AACN ACNPC-AG key terms

AACN ACNPC-AG · Get comfortable with the vocabulary.

Differential diagnosis

A prioritized list of possible conditions that could explain a patient's presenting signs and symptoms, ranked by likelihood and danger so that testing and treatment target the most consequential possibilities first.

Related: Pretest probability, Point-of-care ultrasound (POCUS), Atypical presentation
Pretest probability

The estimated chance that a patient has a particular condition before any test result is known, based on history, examination, and local epidemiology. It helps clinicians decide whether a test can meaningfully change management.

Related: Differential diagnosis, Atypical presentation
Atypical presentation

Illness in older adults that lacks classic symptoms, such as an infection presenting as confusion or a fall rather than fever. Recognition requires a low threshold for evaluation and attention to functional change.

Related: Geriatric syndromes, Delirium, Frailty
Geriatric syndromes

Multifactorial conditions common in older adults, including falls, delirium, incontinence, frailty, and pressure injuries. They rarely have a single cause and often reflect combined effects of aging, disease, and environment.

Related: Frailty, Delirium, Atypical presentation
Frailty

A state of reduced physiologic reserve that increases vulnerability to stressors and adverse outcomes such as falls, hospitalization, and death. It is assessed through gait speed, grip strength, weight loss, exhaustion, and activity level.

Related: Geriatric syndromes, Atypical presentation
Delirium

An acute, fluctuating disturbance of attention and awareness often triggered by infection, medications, pain, or hospitalization. It is a medical emergency associated with falls, prolonged stays, and increased mortality.

Related: Confusion Assessment Method for the ICU (CAM-ICU), Atypical presentation, Geriatric syndromes
Confusion Assessment Method for the ICU (CAM-ICU)

A brief validated tool that identifies delirium in critically ill patients by assessing acute onset or fluctuation, inattention, altered consciousness, and disorganized thinking. It requires trained bedside administration and is repeated during care.

Related: Delirium, Geriatric syndromes
Shock index

The ratio of heart rate to systolic blood pressure. A value above 0.9 suggests occult hypoperfusion and predicts deterioration better than routine vital signs alone in bleeding or septic patients.

Related: Sepsis-3 criteria, Hour-1 sepsis bundle, Fluid responsiveness
Point-of-care ultrasound (POCUS)

Bedside ultrasound performed by the treating clinician to answer focused questions such as cardiac function, lung congestion, or abdominal free fluid. It rapidly narrows the differential and guides procedures.

Related: Differential diagnosis, Fluid responsiveness
Sepsis-3 criteria

Sepsis is life-threatening organ dysfunction caused by a dysregulated response to infection, identified by an acute rise in SOFA score. Septic shock adds vasopressor need and elevated lactate despite adequate fluids.

Related: qSOFA, Hour-1 sepsis bundle, Lactate clearance
qSOFA

A bedside screen for sepsis using respiratory rate 22 or higher, altered mentation, and systolic blood pressure 100 mm Hg or lower. It flags patients at risk but does not by itself define sepsis.

Related: Sepsis-3 criteria, Shock index
Fluid responsiveness

The likelihood that a patient's cardiac output will rise meaningfully after a fluid bolus. It is assessed with dynamic measures such as passive leg raise or pulse pressure variation rather than static pressures alone.

Related: Point-of-care ultrasound (POCUS), Hour-1 sepsis bundle
Hour-1 sepsis bundle

A set of actions started within one hour of recognizing sepsis: measure lactate, obtain blood cultures, give broad-spectrum antibiotics, begin fluids, and use vasopressors for persistent hypotension. Rapid timing aims to reduce mortality.

Related: Sepsis-3 criteria, Lactate clearance, Vasopressor
Lactate clearance

The decline in blood lactate over time, reflecting improved tissue perfusion and response to resuscitation. Failure to clear suggests ongoing hypoperfusion, inadequate source control, or a continuing shock state.

Related: Hour-1 sepsis bundle, Fluid responsiveness
Vasopressor

A medication that constricts blood vessels to raise mean arterial pressure when fluids alone do not restore adequate perfusion. Norepinephrine is first-line for most forms of shock.

Related: Hour-1 sepsis bundle, Shock index
Lung-protective ventilation

A ventilator strategy using low tidal volumes near 6 mL/kg predicted body weight, limited plateau pressures, and appropriate positive end-expiratory pressure. It reduces ventilator-induced lung injury and mortality in acute respiratory distress syndrome.

Related: ARDS Berlin definition, Prone positioning
ARDS Berlin definition

Acute respiratory failure within one week of a known trigger, with bilateral opacities not fully explained by heart failure and hypoxemia graded by the ratio of arterial oxygen partial pressure to inspired oxygen fraction.

Related: Lung-protective ventilation, Prone positioning
Prone positioning

Placing a patient face down for prolonged periods to improve oxygenation in moderate to severe acute respiratory distress syndrome. It reduces mortality when combined with lung-protective ventilation in appropriately selected patients.

Related: ARDS Berlin definition, Lung-protective ventilation
Diabetic ketoacidosis (DKA) protocol

A structured regimen of intravenous fluids, insulin infusion, and electrolyte replacement, especially potassium, with monitoring of glucose, ketones, and anion gap until resolution. It prevents cerebral edema and rebound ketosis.

Related: Hyperosmolar hyperglycemic state (HHS)
Hyperosmolar hyperglycemic state (HHS)

A hyperglycemic emergency marked by severe hyperosmolality, profound dehydration, and altered mental status without significant ketosis. Treatment centers on aggressive fluid replacement and gradual correction of glucose and electrolytes.

Related: Diabetic ketoacidosis (DKA) protocol
Acute coronary syndrome (ACS)

A spectrum of myocardial ischemia including ST-elevation myocardial infarction, non-ST-elevation myocardial infarction, and unstable angina. Immediate priorities are risk stratification, antiplatelet therapy, and reperfusion when indicated.

Related: Differential diagnosis, Point-of-care ultrasound (POCUS)
Targeted temperature management (TTM)

Controlled cooling, often to 32 to 36 degrees Celsius, after cardiac arrest or certain neurologic injuries to reduce reperfusion injury. It requires sedation, shivering control, and slow rewarming.

Beers criteria

A list of medications potentially inappropriate for older adults because of risks such as falls, confusion, or bleeding. It supports safer prescribing and deprescribing during transitions of care.

Related: Deprescribing, Polypharmacy, Geriatric syndromes
Deprescribing

The planned, supervised withdrawal of medications whose harms now outweigh their benefits, especially in older adults with changing goals or limited life expectancy. It requires tapering, monitoring, and patient engagement.

Related: Beers criteria, Polypharmacy, Goals of care
Polypharmacy

The use of multiple medications, often five or more, that raises the risk of interactions, adverse effects, and nonadherence. Assessment should focus on whether each drug has a clear, current indication.

Related: Beers criteria, Deprescribing
Advance care planning

An ongoing conversation about a person's values, goals, and preferences for future medical care, documented and revisited over time. It prepares patients and surrogates for decisions during serious illness.

Related: POLST, Surrogate decision-maker, Goals of care
POLST

A portable medical order form that translates a seriously ill patient's treatment preferences into actionable orders for resuscitation, hospitalization, and comfort care across settings. It complements but does not replace an advance directive.

Related: Advance care planning, Surrogate decision-maker
Social determinants of health

Conditions where people live, work, and receive care, including income, housing, food access, transportation, and social support. They shape disease risk, adherence, and readmission after acute illness.

Related: Transitional care, Health literacy
Health literacy

A person's ability to obtain, understand, and use health information to make decisions. Low health literacy increases medication errors and hospital use, so plain language and teach-back are essential.

Related: Social determinants of health, Transitional care
Transitional care

Coordinated actions that ensure continuity and safety as patients move between hospital, home, rehabilitation, or long-term care. Elements include medication reconciliation, timely follow-up, and clear discharge instructions.

Related: Social determinants of health, Health literacy, Polypharmacy
Surrogate decision-maker

A person authorized to make health care decisions for a patient who lacks capacity, using the patient's known values and, when these are unknown, the patient's best interests. Authority and limits vary by state law.

Related: Advance care planning, Decision-making capacity, Goals of care
Decision-making capacity

A patient's clinical ability to understand relevant information, appreciate consequences, reason through options, and communicate a choice. Capacity is decision-specific and assessed by the clinician, not established by signing a form.

Related: Informed consent, Surrogate decision-maker
Informed consent

A process of disclosing diagnosis, proposed treatment, risks, benefits, alternatives, and consequences of refusal, then confirming voluntary agreement. It requires patient capacity and may involve a surrogate decision-maker.

Related: Decision-making capacity, Surrogate decision-maker
SBAR

A structured communication format covering situation, background, assessment, and recommendation. It reduces omissions and hierarchy barriers during handoffs and urgent consultations.

Related: Quality improvement, Just culture
Just culture

An organizational approach that encourages reporting errors and near misses while distinguishing human error, at-risk behavior, and reckless conduct for a fair, proportionate response. It supports learning and patient safety.

Related: Quality improvement, SBAR
Quality improvement

A systematic, data-driven approach to closing gaps between current and desired care using cycles such as plan-do-study-act. It engages frontline teams and measures whether changes produce lasting improvement.

Related: Just culture, SBAR
Goals of care

The patient's prioritized health outcomes and acceptable burdens of treatment, clarified through discussion and used to guide decisions. They should be revisited whenever prognosis, preferences, or clinical status changes.

Related: Advance care planning, Surrogate decision-maker, Futility
Futility

A judgment that an intervention cannot achieve its intended physiologic or patient-centered goal. Disagreements require careful communication, ethics consultation, and respect for surrogate authority within legal limits.

Related: Goals of care, Surrogate decision-maker