MCCQE Part I study materials
MCCQE Part I study resources

MCCQE Part I key terms

MCCQE Part I · Get comfortable with the vocabulary.

History of present illness

A structured account of the onset, course, character, severity, timing, and modifying factors of a patient's current problem, plus associated symptoms and the patient's own concerns and expectations.

Related: Review of systems, Differential diagnosis, Red flag symptom
Review of systems

A systematic screen of symptoms by organ system, asked after the main history, to uncover problems the patient has not volunteered and to guide the physical examination.

Related: History of present illness, Red flag symptom
Past medical history

A record of prior illnesses, surgeries, hospitalizations, injuries, immunizations, and chronic conditions that shape the patient's current risk and management options.

Related: Medication reconciliation, Comorbidity
Medication reconciliation

The formal process of obtaining and comparing a complete list of a patient's medications, including over-the-counter products and supplements, across care transitions to prevent errors and interactions.

Related: Past medical history, Polypharmacy, Adverse drug event
Differential diagnosis

A prioritized list of plausible explanations for a patient's presentation, ranked by likelihood and by the harm of missing each condition, used to direct further testing.

Related: History of present illness, Red flag symptom, Pretest probability
Red flag symptom

A feature in the history or examination that signals possible serious or urgent disease and prompts expedited investigation or referral rather than routine management.

Related: Differential diagnosis, Safety netting
Pretest probability

The estimated likelihood that a patient has a condition before a test is performed, based on history, examination, and local prevalence; it determines how a test result should be interpreted.

Related: Sensitivity, Specificity, Likelihood ratio
Sensitivity

The proportion of people who truly have a condition and are correctly identified by a test; a highly sensitive test is useful for ruling a condition out when negative.

Related: Specificity, Pretest probability, Likelihood ratio
Specificity

The proportion of people without a condition who are correctly identified as negative by a test; a highly specific test is useful for ruling a condition in when positive.

Related: Sensitivity, Pretest probability, Likelihood ratio
Likelihood ratio

A ratio expressing how much a given test result changes the odds of disease; values far from one substantially shift post-test probability and support clinical decisions.

Related: Pretest probability, Sensitivity, Specificity
Number needed to treat

The number of patients who must receive an intervention for one additional person to benefit, calculated as the reciprocal of the absolute risk reduction.

Related: Absolute risk reduction, Evidence-based medicine
Absolute risk reduction

The arithmetic difference in event rates between control and treatment groups, reflecting the actual size of benefit a patient may expect from an intervention.

Related: Number needed to treat, Evidence-based medicine
Evidence-based medicine

The integration of the best available research evidence with clinical expertise and the patient's values and circumstances when making decisions about care.

Related: Number needed to treat, Shared decision-making, Clinical practice guideline
Clinical practice guideline

Systematically developed recommendations intended to help clinicians and patients make decisions about appropriate care for specific clinical circumstances, ideally adapted to local context.

Related: Evidence-based medicine, Choosing Wisely
Choosing Wisely

A campaign of recommendations identifying tests and treatments that are commonly overused and offer little benefit, encouraging clinicians to discuss necessity and avoid low-value care.

Related: Clinical practice guideline, Resource stewardship
Resource stewardship

The responsible use of limited health care resources, balancing benefit to the individual patient against the needs of the wider population, without withholding effective care.

Related: Choosing Wisely, Wait time, Allocation of scarce resources
Comorbidity

The presence of one or more additional conditions alongside an index disease, which can complicate treatment, affect prognosis, and change the risk-benefit balance of interventions.

Related: Polypharmacy, Frailty
Polypharmacy

The concurrent use of multiple medications, often five or more, which raises the risk of interactions, adverse effects, and non-adherence, particularly in older adults.

Related: Medication reconciliation, Adverse drug event, Deprescribing
Deprescribing

The planned, supervised withdrawal of medications that are no longer beneficial or are causing harm, undertaken with the patient to reduce pill burden and adverse effects.

Related: Polypharmacy, Adverse drug event
Adverse drug event

Any injury or harm resulting from a medication, whether from an error, an interaction, an allergic reaction, or an expected side effect at a therapeutic dose.

Related: Polypharmacy, Medication reconciliation, Deprescribing
Informed consent

A patient's voluntary agreement to a treatment or procedure after receiving and understanding information about its purpose, benefits, risks, and reasonable alternatives.

Related: Capacity, Shared decision-making, Substitute decision-maker
Capacity

A patient's ability to understand relevant information and appreciate the consequences of a specific decision at a specific time; it is decision-specific rather than global.

Related: Informed consent, Substitute decision-maker, Advance care plan
Substitute decision-maker

A person legally authorized to make health care decisions on behalf of a patient who lacks capacity, guided by the patient's previously expressed wishes or best interests.

Related: Capacity, Advance care plan, Informed consent
Advance care plan

A process of discussing and recording a patient's values, goals, and preferences for future care, used to guide decisions if the patient later loses capacity.

Related: Substitute decision-maker, Goals of care, Capacity
Goals of care

The agreed aims of a patient's treatment, such as cure, prolonging life, comfort, or function, which direct which interventions are appropriate as illness progresses.

Related: Advance care plan, Shared decision-making, Substitute decision-maker
Shared decision-making

A collaborative conversation in which clinician and patient exchange evidence and values to reach a mutually agreed choice among reasonable options.

Related: Informed consent, Goals of care, Decision aid
Decision aid

A tool that presents the options, benefits, and harms of a health decision in plain language, helping patients clarify values and participate meaningfully in shared decision-making.

Related: Shared decision-making, Health literacy
Health literacy

A patient's ability to obtain, understand, and use health information to make decisions; low health literacy requires plain language, teach-back, and extra support.

Related: Decision aid, Teach-back method, Interpretation services
Teach-back method

A communication technique in which the clinician asks the patient to restate information in their own words, confirming understanding and revealing gaps to be addressed.

Related: Health literacy, Interpretation services
Interpretation services

Professional language support used when clinician and patient do not share a fluent language, avoiding errors and inequity that arise from using untrained interpreters such as family members.

Related: Health literacy, Teach-back method
Safety netting

Advice given to a patient about what to expect, which symptoms should prompt return, and how to access care urgently if the condition worsens or fails to improve.

Related: Red flag symptom, Closed-loop communication
Closed-loop communication

A team communication pattern in which a message is sent, repeated back by the receiver, and confirmed by the sender, reducing error in high-stakes handovers and orders.

Related: Handover, SBAR
SBAR

A structured communication format (Situation, Background, Assessment, Recommendation) used to convey concise, prioritized information between clinicians, especially when escalating concerns.

Related: Closed-loop communication, Handover
Handover

The transfer of responsibility and essential clinical information between care providers, which should be structured, complete, and allow the receiver to ask questions.

Related: SBAR, Closed-loop communication
Interprofessional collaboration

Working with professionals from different disciplines, sharing roles and information, to plan and deliver coordinated care that no single provider could achieve alone.

Related: Handover, Conflict resolution, Scope of practice
Scope of practice

The activities, responsibilities, and limits of a health professional's role as defined by training, legislation, and employer policy, which must be respected when delegating or sharing care.

Related: Interprofessional collaboration, Delegation
Delegation

The transfer of a specific task to another team member who is competent to perform it, with the delegator retaining accountability for appropriate supervision and follow-up.

Related: Scope of practice, Interprofessional collaboration
Conflict resolution

A structured approach to disagreement within a team that separates people from problems, explores interests, and seeks a mutually acceptable solution, escalating formally if needed.

Related: Interprofessional collaboration, Just culture
Just culture

An organizational approach that distinguishes human error from reckless behavior, encouraging reporting of mistakes while holding people accountable for unsafe choices.

Related: Patient safety incident, Conflict resolution, Quality improvement
Patient safety incident

An event or near miss that could have caused or did cause harm to a patient; it should be disclosed, reported, and analyzed to prevent recurrence.

Related: Just culture, Quality improvement, Disclosure of harm
Disclosure of harm

An open, timely conversation with a patient or family after an adverse event, explaining what happened, expressing regret, and outlining what will be done next.

Related: Patient safety incident, Just culture
Quality improvement

A systematic, data-driven method for continuously improving care processes and outcomes, often using plan-do-study-act cycles and measured indicators.

Related: Just culture, Audit and feedback
Audit and feedback

A quality improvement approach that compares a clinician's or team's performance against a standard and provides targeted feedback to close the identified gap.

Related: Quality improvement, Clinical practice guideline
Wait time

The interval a patient waits for an appointment, diagnostic test, or procedure; it is a key access measure that clinicians can influence through prioritization and appropriate referral.

Related: Resource stewardship, Triage
Triage

The process of sorting patients by urgency of need so that limited time and resources are directed first to those who will benefit most or deteriorate soonest.

Related: Wait time, Allocation of scarce resources, Red flag symptom
Allocation of scarce resources

Decisions about distributing limited health care goods such as beds, organs, or staff, guided by transparent criteria of need, benefit, and fairness.

Related: Resource stewardship, Triage, Wait time
Frailty

A state of reduced physiological reserve and increased vulnerability to stressors, which predicts poorer outcomes and should prompt adjusted treatment goals and supports.

Related: Comorbidity, Goals of care, Polypharmacy