COMLEX Level 1 study materials
COMLEX Level 1 study resources

COMLEX Level 1 cheat sheet

COMLEX Level 1 · Keep the key ideas within reach.

Quick reference

Osteopathic Principles, Practice, and Manipulative Treatment

  • Somatic dysfunction is diagnosed by TART: Tissue texture change, Asymmetry of landmarks, Restriction of motion, and Tenderness; at least one element must be documented.

  • Fryette law I describes neutral, group curves of the thoracic and lumbar spine: sidebending precedes rotation, and the two are coupled to opposite sides.

  • Fryette law II describes a non-neutral single vertebral unit in which sidebending and rotation occur to the same side, most often in the lumbar spine.

  • HVLA is relatively contraindicated in severe osteoporosis, metastatic bone disease, acute fracture, joint instability, myelopathy, and vertebrobasilar insufficiency for cervical techniques.

  • Muscle energy technique uses a patient-generated isometric contraction against operator counterforce, exploiting post-isometric relaxation to lengthen a restricted muscle.

  • Counterstrain places the patient in the position of comfort that reduces the tender point for roughly 90 seconds, then returns slowly to neutral.

  • The five osteopathic models of patient care are biomechanical, respiratory-circulatory, neurological, behavioral, and metabolic-nutritional.

  • The primary respiratory mechanism comprises CNS motility, CSF fluctuation, dural tension, cranial bone mobility, and involuntary sacral motion; the cranial rhythmic impulse normally runs 10-14 cycles per minute.

  • Lymphatic technique mobilizes edema and improves immune flow; the thoracic duct empties at the junction of the left internal jugular and left subclavian veins.

Quick reference

Osteopathic Patient Care and Procedural Skills

  • The SOAP note organizes documentation into Subjective, Objective, Assessment, and Plan.

  • Order of draw: blood culture bottles first, then light blue (citrate), serum red/gold, green heparin, lavender EDTA, and gray fluoride-oxalate.

  • Lumbar puncture is performed at L3-L4 or L4-L5, at or below Tuffier's line through the iliac crests, which lies below the conus medullaris in adults.

  • Thoracentesis is entered one to two rib spaces below the upper fluid level, typically the 7th-8th intercostal space in the posterior midscapular line, passing just above the rib to avoid the neurovascular bundle.

  • Paracentesis is performed in the left lower quadrant, about 2 cm below the umbilicus and lateral to the rectus sheath, avoiding the inferior epigastric vessels.

  • Valid informed consent requires decisional capacity, disclosure of risks, benefits, and alternatives, voluntariness, and documentation.

  • Nonabsorbable sutures are removed at about 4-5 days on the face, 7-10 days on the scalp and trunk, and 10-14 days on the extremities.

  • Standard precautions treat all blood and body fluids as potentially infectious: gloves for contact, gown and mask for splash risk, and hand hygiene before and after every patient encounter.

Quick reference

Application of Knowledge for Osteopathic Medical Practice

  • Sensitivity = TP/(TP+FN); a highly sensitive test that is negative rules out disease (SnNout).

  • Specificity = TN/(TN+FP); a highly specific test that is positive rules in disease (SpPin).

  • PPV = TP/(TP+FP) and NPV = TN/(TN+FN); both change with disease prevalence, whereas sensitivity and specificity do not.

  • Positive likelihood ratio = sensitivity/(1 - specificity); an LR greater than 10 substantially increases post-test probability.

  • Absolute risk reduction = control event rate minus treatment event rate, and number needed to treat = 1/ARR.

  • Type I error (alpha) is rejecting a true null hypothesis; type II error (beta) is failing to reject a false null; power = 1 - beta.

  • Phase I trials establish safety and dosing, phase II assess efficacy and dose ranging, phase III compare with standard therapy in large randomized samples, and phase IV is post-marketing surveillance.

  • Relative risk is calculated in cohort studies and odds ratio in case-control studies; the odds ratio approximates relative risk only when the outcome is rare, under about 10%.

  • Incidence counts new cases per population at risk over time, while prevalence counts all existing cases at a point in time; prevalence approximates incidence multiplied by disease duration.

Quick reference

Practice-Based Learning and Improvement in Osteopathic Medical Practice

  • The PDSA (Plan-Do-Study-Act) cycle tests small changes iteratively and measures results before system-wide spread.

  • Evidence hierarchy from strongest: systematic reviews or meta-analyses of randomized trials, individual randomized trials, cohort studies, case-control studies, case series or reports, then expert opinion.

  • The five evidence-based medicine steps are assess the patient, ask a focused question, acquire the evidence, appraise it, and apply it with self-evaluation.

  • The PICO format frames a clinical question as Population, Intervention, Comparison, and Outcome.

  • Root cause analysis is a systems-based review after an adverse event that identifies process failures rather than assigning individual blame.

  • The six ACGME core competencies are patient care, medical knowledge, practice-based learning and improvement, interpersonal and communication skills, professionalism, and systems-based practice.

  • SMART learning objectives are Specific, Measurable, Achievable, Relevant, and Time-bound.

  • Deliberate practice requires specific goals, immediate feedback, and repeated performance just beyond the learner's current ability level.

Quick reference

Interpersonal and Communication Skills in the Practice of Osteopathic Medicine

  • SPIKES structures delivery of bad news: Setting, Perception, Invitation, Knowledge, Empathy, and Strategy or Summary.

  • OARS micro-skills are Open-ended questions, Affirmations, Reflections, and Summaries.

  • Motivational interviewing rolls with resistance rather than confronting it, supporting patient autonomy and self-efficacy for behavior change.

  • NURSE statements respond to emotion: Naming, Understanding, Respecting, Supporting, and Exploring.

  • Teach-back asks the patient to restate the plan in their own words and detects limited health literacy better than asking whether they understand.

  • Use a trained medical interpreter rather than a family member for patients with limited English proficiency, and document the interpreter's identity.

  • Plain-language written materials should target roughly a 5th-6th grade reading level to match average US adult health literacy.

  • SBAR structures handoffs as Situation, Background, Assessment, and Recommendation.

Quick reference

Professionalism in the Practice of Osteopathic Medicine

  • Fiduciary duty requires the physician to place the patient's interests above self-interest, encompassing competence, confidentiality, and loyalty.

  • Financial and research conflicts of interest must be disclosed to patients, institutions, and journals, and managed or recused when material.

  • HIPAA permits disclosure without patient authorization for public health reporting, suspected abuse or neglect, imminent serious threat to an identifiable person, and court orders or subpoenas.

  • Informed refusal by a patient with decisional capacity must follow disclosure of risks and alternatives and should be documented in the record.

  • A physician impaired by substance use or illness should be referred to a physician health program; abrupt termination of care that abandons patients is never acceptable.

  • Sexual contact with a current patient is a boundary violation and is prohibited regardless of patient consent.

  • Medical errors that reach and harm patients should be disclosed promptly and fully, with apology, explanation, and a plan to prevent recurrence.

  • Core professional attributes include altruism, accountability, excellence, duty, honor and integrity, and respect for others.

Quick reference

Systems-Based Practice in Osteopathic Medicine

  • The Institute of Medicine six aims describe care that is safe, effective, patient-centered, timely, efficient, and equitable.

  • Diagnosis-related group prospective payment pays hospitals a fixed amount per discharge by diagnosis, incentivizing shorter stays and lower cost per case.

  • Medicare Part A covers inpatient hospital care, Part B outpatient and physician services, Part C Medicare Advantage plans, and Part D outpatient prescription drugs.

  • HMOs use in-network primary care gatekeeping, PPOs allow out-of-network care at higher cost sharing, and POS plans blend the two models.

  • Medicare physician payment equals the sum of work, practice expense, and malpractice RVUs multiplied by the geographic practice cost index and a conversion factor.

  • A patient-centered medical home delivers coordinated, accessible, comprehensive primary care with emphasis on prevention and quality measurement.

  • Accountable care organizations share savings or losses with payers when they meet quality and total-cost benchmarks for an assigned population.

  • Never events such as wrong-site surgery or a retained foreign body are serious, largely preventable errors that payers do not reimburse.

  • A quality-adjusted life year weights survival by utility from 0 (death) to 1 (perfect health), and cost per QALY compares interventions across diseases.