DABT case studies
DABT · Put your knowledge to work in context.
The Diplomate of the American Board of Toxicology (DABT) is a board certification for toxicologists - a credential earned by passing an examination administered by the American Board of Toxicology and maintained afterward according to the Board's requirements. It is aimed at scientists whose work involves evaluating hazard and risk: toxicologists in industry, contract research organizations, government agencies, academia, and consulting. The DABT case studies are 5 cases and about 3,998 words.
1Toluene Urinary Metabolites: Sampling Timing, Saturation, and the Obese Worker
A laminating plant uses a toluene-based contact cement applied by hand (no local exhaust, cotton gloves only). Personal 8-hour air sampling gives a TWA of 95 ppm (ACGIH TLV 20 ppm; OSHA PEL 200 ppm).
769 words, about 4 min2Dapsone-Induced Methemoglobinemia with a 'Normal' G6PD Result
A 34-year-old woman taking dapsone 100 mg daily for six weeks presents with fatigue, headache, and central cyanosis. Pulse oximetry reads 88% and does not improve on 15 L/min oxygen; arterial PaO2 is 95 mmHg.
736 words, about 4 min3Cholinesterase Depression in an Orchard Worker: Carbamate, Organophosphate, or Both?
A 38-year-old orchard worker is brought in 3 hours after spraying insecticide without PPE, with miosis, salivation, bronchorrhea, vomiting, bradycardia of 46, and muscle fasciculations. He improves after three 2 mg IV doses of atropine.
762 words, about 4 min4Deriving an RfD from a BMDL10 and Comparing It with an Occupational Aerosol Exposure
A two-year rat drinking-water study of a non-genotoxic chlorinated by-product reports dose-related centrilobular hepatocellular hypertrophy and vacuolation. Benchmark dose modeling of liver hypertrophy gives a BMDL10 of 20 mg/kg-day; the NOAEL by pairwise testing is 30 mg/kg-day and the LOAEL 60 mg/kg-day.
823 words, about 4 min5A Non-Monotonic Liver Signal in a 28-Day Study: Real Effect or Artifact?
A contract laboratory runs a 28-day GLP oral gavage study in Sprague-Dawley rats at 0, 10, 50, 250 and 1000 mg/kg-day, 5/sex/group. At 50 mg/kg-day, mean liver weight is 12% above control (p<0.05) and ALT is 2.1x control (p<0.05), with no histologic change.
908 words, about 5 min