EAU Entrance Exam flashcards
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- D'Amico risk groups
- Prostate cancer stratification using PSA, Gleason score, and clinical T stage: low, intermediate, and high risk. It guides treatment selection such as active surveillance, radiotherapy, or radical prostatectomy.
- BCG intravesical therapy
- Bacillus Calmette-Guérin instilled into the bladder for high-risk non-muscle-invasive urothelial carcinoma, including CIS. It reduces recurrence and progression by inducing local immune activation.
- Renal cell carcinoma subtypes
- Clear cell carcinoma is the most common type, associated with VHL inactivation. Papillary and chromophobe subtypes have different genetics and generally lower responses to VEGF-targeted therapy.
- Testicular tumor markers
- Alpha-fetoprotein is elevated in non-seminomatous germ cell tumors but never in pure seminoma. Beta-HCG can be elevated in both. Markers guide diagnosis, staging, and monitoring.
- PDE5 inhibitor contraindication
- PDE5 inhibitors are contraindicated with nitrates because both cause vasodilation and can produce severe hypotension. They are also used cautiously with alpha-blockers and in severe cardiovascular disease.
- Ischemic priapism management
- Ischemic priapism is a painful, rigid erection lasting over four hours and is an emergency. Treatment includes aspiration, irrigation, and intracavernosal phenylephrine; surgery is needed if conservative measures fail.
- Varicocele laterality
- About 90% of varicoceles occur on the left because the left internal spermatic vein drains at a right angle into the left renal vein, increasing venous pressure. Right-sided varicocele warrants imaging.
- Premature ejaculation treatment
- Lifelong premature ejaculation begins with first sexual experiences; acquired forms develop later. Behavioral techniques, topical anesthetics, and SSRIs such as dapoxetine are treatment options.
- Struvite stone management
- Struvite stones form from urease-producing bacteria such as Proteus and cause staghorn calculi. Treatment requires complete stone removal plus eradication of infection to prevent recurrence.
- Uric acid stone features
- Uric acid stones are radiolucent on plain radiography and form in acidic urine. They can be dissolved by alkalinizing urine with potassium citrate and increasing fluid intake.
- PCNL indications
- Percutaneous nephrolithotomy is first-line for renal stones larger than 20 mm and for lower pole stones over 10–15 mm. It has higher stone-free rates than shockwave lithotripsy for large stones.
- Shockwave lithotripsy limits
- Shockwave lithotripsy works best for stones under 20 mm with low density and short skin-to-stone distance. It is contraindicated in pregnancy, coagulopathy, and untreated urinary infection.
- Stress incontinence first-line
- Stress urinary incontinence is leakage with effort or sneezing due to urethral sphincter weakness. Pelvic floor muscle training is first-line; midurethral sling is standard surgical treatment.
- Overactive bladder step therapy
- Overactive bladder treatment starts with behavioral therapy and bladder training, then antimuscarinics or mirabegron. Third-line options include onabotulinumtoxinA, sacral neuromodulation, and tibial nerve stimulation.
- Nocturnal polyuria definition
- Nocturnal polyuria is present when nocturnal urine volume exceeds one-third of the 24-hour urine volume. It is a common cause of nocturia and is assessed with a bladder diary.
- POP-Q staging
- The Pelvic Organ Prolapse Quantification system measures prolapse at defined vaginal points relative to the hymen. Stage 0 is no prolapse; stage IV is complete eversion.
- Uncomplicated cystitis treatment
- First-line options include nitrofurantoin for five days, fosfomycin as a single dose, and trimethoprim-sulfamethoxazole for three days when local resistance is below 20%. Fluoroquinolones are reserved.
- Complicated UTI with obstruction
- Fever with ureteral obstruction requires urgent decompression by stent or nephrostomy plus culture-directed antibiotics. Antibiotics alone are insufficient and risk sepsis and renal loss.
- Fournier gangrene
- Fournier gangrene is necrotizing fasciitis of the perineum and genitalia, usually polymicrobial and associated with diabetes. It requires urgent surgical debridement and broad-spectrum antibiotics.
- Epididymitis pathogens
- In sexually active young men, Chlamydia trachomatis and Neisseria gonorrhoeae are common causes. Older men more often have Gram-negative enteric organisms. Treatment includes ceftriaxone plus doxycycline when STI is suspected.
- Vesicoureteral reflux grading
- Reflux is graded I to V by the extent of retrograde flow on voiding cystourethrography. Lower grades often resolve spontaneously; higher grades and breakthrough infections may need surgery.
- Hypospadias triad
- Hypospadias consists of a ventral meatus, ventral penile curvature called chordee, and a dorsal hood. Circumcision should be deferred before repair, which is usually done at 6–18 months.
- Orchiopexy timing
- For an undescended testis not descended by six months, orchiopexy is recommended, ideally by 12–18 months. Early surgery reduces risks of infertility and testicular malignancy.
- Posterior urethral valves
- Posterior urethral valves cause antenatal hydronephrosis, a thick-walled bladder, and bilateral hydroureteronephrosis in male infants. Diagnosis is confirmed by voiding cystourethrography and treated with catheter drainage and valve ablation.
- Renal transplant immunosuppression
- Maintenance therapy typically combines tacrolimus, mycophenolate, and corticosteroids after induction with basiliximab or anti-thymocyte globulin. Regimens are individualized by immunologic risk and donor type.
- Hyperacute rejection
- Hyperacute rejection occurs within minutes due to preformed donor-specific antibodies. The graft becomes cyanotic and nonfunctioning; treatment is immediate graft removal and prevention by crossmatching.
- Renal artery aneurysm repair
- Most renal artery aneurysms are asymptomatic and managed by surveillance. Intervention is considered for size over 2 cm, rapid growth, or in women of childbearing age.
- Urethral injury evaluation
- Blood at the meatus or a high-riding prostate after trauma suggests urethral injury. Catheterization is avoided; retrograde urethrogram defines the site and extent of injury.
- Bladder rupture types
- Extraperitoneal bladder rupture after pelvic fracture is often managed with catheter drainage. Intraperitoneal rupture requires surgical repair because urine leaks into the peritoneal cavity.
- Penile fracture repair
- Penile fracture presents with a snap, detumescence, and hematoma from a torn tunica albuginea. Emergent surgical repair is standard; urethral injury coexists in 10–20% of cases.
- Bosniak classification
- The Bosniak system classifies renal cysts by CT features. Categories I and II are benign, III is indeterminate, and IV is malignant; contrast enhancement is the key feature.
- Urodynamic pressure-flow study
- A pressure-flow study during voiding distinguishes bladder outlet obstruction from detrusor underactivity. High pressure with low flow suggests obstruction; low pressure with low flow suggests underactivity.