MDCG Medical Exam study materials
MDCG Medical Exam study resources

MDCG Medical Exam key terms

MDCG Medical Exam · Get comfortable with the vocabulary.

Informed consent

A patient's voluntary agreement to a test or treatment after receiving clear information about its purpose, benefits, risks, and reasonable alternatives, including the option to decline.

Related: Decision-making capacity, Confidentiality
Decision-making capacity

A clinician's bedside judgment that a patient can understand relevant information, appreciate the consequences of choices, reason through options, and communicate a consistent decision about their own care.

Related: Informed consent, Advance directive
Advance directive

A written or witnessed statement made while a patient has capacity, naming a surrogate or specifying preferred treatments, that guides care if the patient later loses the ability to decide.

Related: Decision-making capacity, Do not resuscitate order
Confidentiality

The professional duty to keep patient information private and share it only with those involved in care or where law permits or requires disclosure, such as reportable diseases or imminent harm.

Related: Informed consent, Protected health information
Negligence (medical malpractice)

Failure to meet the accepted standard of care that causes harm, established by showing a duty to the patient, a breach of that duty, causation, and resulting damages.

Related: Standard of care, Root cause analysis
Standard of care

The level and type of care that a reasonably competent clinician with similar training would provide in similar circumstances, often established through guidelines, expert testimony, and customary practice.

Related: Negligence (medical malpractice), Clinical practice guideline
Do not resuscitate order

A documented medical order, authorized by the patient or surrogate, instructing clinicians not to attempt cardiopulmonary resuscitation if the patient suffers cardiac or respiratory arrest.

Related: Advance directive, Goals of care discussion
Goals of care discussion

A conversation among clinicians, the patient, and family that clarifies the patient's values and priorities and aligns treatment plans, including intensity of intervention, with those preferences.

Related: Advance directive, Do not resuscitate order
Patient history and physical examination

The structured interview and hands-on assessment that generate the initial differential diagnosis and direct subsequent testing, forming the foundation of every clinical encounter.

Related: Differential diagnosis, Review of systems
Review of systems

A systematic series of questions covering each organ system to uncover symptoms the patient may not volunteer, helping to broaden or narrow the diagnostic possibilities.

Related: Patient history and physical examination, Differential diagnosis
Differential diagnosis

A ranked list of possible conditions that could explain a patient's presentation, refined over time as history, examination, and test results make some options more or less likely.

Related: Patient history and physical examination, Pretest probability
Pretest probability

The estimated likelihood that a patient has a condition before a test is performed, which determines how much a positive or negative result actually changes the clinical picture.

Related: Sensitivity and specificity, Positive predictive value
Sensitivity and specificity

Sensitivity is the proportion of truly diseased patients who test positive; specificity is the proportion of truly healthy patients who test negative. Both describe test performance independent of how common the disease is.

Related: Positive predictive value, Pretest probability
Positive predictive value

The probability that a patient with a positive test result actually has the disease. It rises as disease prevalence in the tested population rises, unlike sensitivity and specificity.

Related: Sensitivity and specificity, Pretest probability
Number needed to treat

The number of patients who must receive an intervention for one additional patient to benefit, calculated as the reciprocal of the absolute risk reduction.

Related: Absolute risk reduction, Relative risk
Relative risk

The ratio of the risk of an outcome in an exposed group to the risk in an unexposed group, expressing how many times more or less likely the outcome is with exposure.

Related: Absolute risk reduction, Odds ratio
Absolute risk reduction

The arithmetic difference in event rates between a control group and a treated group, showing the actual change in risk rather than a proportional one.

Related: Number needed to treat, Relative risk
Odds ratio

The ratio of the odds of exposure among cases to the odds of exposure among controls, commonly used in case-control studies and as an approximation of relative risk for rare outcomes.

Related: Relative risk, Case-control study
Case-control study

An observational design that identifies people with an outcome and comparable people without it, then looks back at prior exposures. It is efficient for rare diseases but vulnerable to recall and selection bias.

Related: Odds ratio, Selection bias
Selection bias

A distortion that arises when the groups compared differ systematically in ways related to both exposure and outcome, often because of how participants were recruited or retained.

Related: Case-control study, Confounding
Confounding

Distortion of an exposure-outcome association by a third factor that is linked to both, creating an apparent relationship that does not reflect a causal effect of the exposure.

Related: Selection bias, Randomized controlled trial
Randomized controlled trial

An experimental study in which participants are assigned by chance to intervention or control groups, so that known and unknown confounders are expected to balance between groups.

Related: Confounding, Intention-to-treat analysis
Intention-to-treat analysis

An analysis that includes every participant in the group to which they were originally assigned, regardless of whether they completed or adhered to the assigned treatment.

Related: Randomized controlled trial, Clinical practice guideline
Clinical practice guideline

Systematically developed statements that translate evidence into recommendations for specific clinical circumstances, intended to support but not replace individualized clinician judgment.

Related: Standard of care, Intention-to-treat analysis
Pharmacokinetics

How the body handles a drug over time, encompassing absorption, distribution, metabolism, and elimination, which together determine the concentration of drug at its site of action.

Related: Therapeutic index, Half-life
Half-life

The time required for the plasma concentration of a drug to fall by half, useful for estimating how long a drug persists and how long to wait to reach steady state with repeated dosing.

Related: Pharmacokinetics, Steady state
Steady state

The condition reached during regular dosing when the amount of drug entering the body equals the amount being eliminated, so concentrations fluctuate within a stable range.

Related: Half-life, Therapeutic index
Therapeutic index

A measure of a drug's safety margin, comparing the dose that produces toxicity with the dose that produces the desired effect; a narrow index demands closer monitoring.

Related: Pharmacokinetics, Adverse drug event
Adverse drug event

Any injury resulting from medication use, including allergic reactions, dosing errors, interactions, and expected side effects, whether or not the medication was prescribed appropriately.

Related: Therapeutic index, Medication reconciliation
Medication reconciliation

A structured process of comparing a patient's complete medication list across care transitions to identify omissions, duplications, and dangerous interactions before orders are written.

Related: Adverse drug event, Handoff communication
Handoff communication

The transfer of patient information and responsibility between clinicians or teams, ideally using a standardized structure so that critical details and pending tasks are not lost.

Related: Medication reconciliation, Root cause analysis
Root cause analysis

A retrospective, team-based method for investigating a serious adverse event by tracing contributing system factors and identifying changes that would prevent recurrence.

Related: Handoff communication, Never event
Never event

A clearly identifiable, serious patient harm incident that is largely preventable, such as wrong-site surgery or transfusion of the wrong blood type, and that signals a system failure.

Related: Root cause analysis, Standard of care
Protected health information

Individually identifiable health information held or transmitted by a covered entity or its business associate, subject to privacy and security rules governing its use and disclosure.

Related: Confidentiality, Medical coding
Medical coding

The translation of diagnoses, procedures, and services into standardized alphanumeric codes used for billing, claims processing, and population health statistics.

Related: Protected health information, Clinical documentation integrity
Clinical documentation integrity

The practice of ensuring that the medical record accurately and completely reflects the patient's severity of illness, care provided, and outcomes, supporting both quality measurement and correct reimbursement.

Related: Medical coding, Protected health information
Triage

The rapid sorting of patients by urgency of need so that limited resources are directed first to those who will deteriorate or die without prompt intervention.

Related: ABCDE assessment, Sepsis
ABCDE assessment

A prioritized approach to the deteriorating patient that sequentially evaluates airway, breathing, circulation, disability, and exposure, treating each threat before moving on.

Related: Triage, Sepsis
Sepsis

Life-threatening organ dysfunction caused by a dysregulated host response to infection, requiring prompt recognition, cultures, antibiotics, and fluid resuscitation to limit mortality.

Related: Triage, ABCDE assessment