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Question 1Anatomy and Physiology
Which structure separates the thoracic cavity from the abdominal cavity?
- The pleura
- The diaphragm Correct answer.
- The peritoneum
- The mediastinum
Explanation
The diaphragm is a dome-shaped skeletal muscle that forms the floor of the thoracic cavity and the roof of the abdominal cavity, and its contraction drives inspiration. The mediastinum is the central compartment of the thorax, while peritoneum and pleura are serous membranes lining the abdomen and lungs respectively.
Question 2Anatomy and Physiology
Which formed element of blood is primarily responsible for oxygen transport?
- Lymphocytes
- Erythrocytes Correct answer.
- Platelets
- Monocytes
Explanation
Erythrocytes (red blood cells) contain haemoglobin, which binds oxygen in the pulmonary capillaries and releases it in peripheral tissues. The other listed elements serve haemostasis or immune defence rather than gas transport.
Question 3Anatomy and Physiology
In the cardiac cycle, closure of the atrioventricular valves produces which heart sound?
- The third heart sound
- The second heart sound
- The fourth heart sound
- The first heart sound Correct answer.
Explanation
The first heart sound (S1) results from closure of the mitral and tricuspid valves at the onset of ventricular systole. The second sound arises from semilunar valve closure, while S3 and S4 relate to ventricular filling.
Question 4Anatomy and Physiology
Which type of epithelium lines the alveoli of the lungs and best supports gas diffusion?
- Simple cuboidal epithelium
- Stratified squamous epithelium
- Pseudostratified columnar epithelium
- Simple squamous epithelium Correct answer.
Explanation
Simple squamous epithelium is a single layer of flattened cells, giving the minimal thickness required for efficient diffusion of oxygen and carbon dioxide across the alveolar wall. Thicker or stratified epithelia would impede gas exchange.
Question 5Anatomy and Physiology
Which cranial nerve carries the majority of parasympathetic outflow to the thoracic and abdominal viscera?
- The glossopharyngeal nerve
- The vagus nerve Correct answer.
- The facial nerve
- The oculomotor nerve
Explanation
The vagus nerve (cranial nerve X) provides extensive parasympathetic supply to the heart, lungs and most of the gastrointestinal tract. The other listed cranial nerves carry parasympathetic fibres to more limited targets such as salivary glands and the pupil.
Question 6Anatomy and Physiology
Which hormone is released from the posterior pituitary?
- Antidiuretic hormone Correct answer.
- Adrenocorticotropic hormone
- Thyroid-stimulating hormone
- Prolactin
Explanation
Antidiuretic hormone and oxytocin are produced in hypothalamic neurons and released from the posterior pituitary. The other listed hormones are secreted by the anterior pituitary under hypothalamic control.
Question 7Anatomy and Physiology
Which region of the nephron is the principal site of glucose reabsorption?
- The collecting duct
- The distal convoluted tubule
- The descending limb of the loop of Henle
- The proximal convoluted tubule Correct answer.
Explanation
The proximal convoluted tubule reabsorbs nearly all filtered glucose via sodium-coupled cotransporters, so glucose is normally absent from urine. More distal segments reabsorb little or no glucose.
Question 8Anatomy and Physiology
Which bone of the appendicular skeleton forms the socket of the hip joint?
- The ilium Correct answer.
- The femur
- The sacrum
- The ischium
Explanation
The acetabulum, which forms the hip socket, is contributed mainly by the ilium together with parts of the ischium and pubis. The sacrum is part of the axial skeleton and the femur forms the head of the joint.
Question 9Anatomy and Physiology
A patient has a lesion of the left corticospinal tract above the level of the medullary decussation. Which pattern of weakness is expected?
- Ipsilateral spastic weakness
- Contralateral flaccid weakness
- Ipsilateral flaccid weakness
- Contralateral spastic weakness Correct answer.
Explanation
Upper motor neuron lesions produce spastic weakness, and because corticospinal fibres cross in the medulla, a lesion above the decussation causes contralateral deficits. Flaccid weakness would indicate a lower motor neuron lesion.
Question 10Anatomy and Physiology
During strenuous exercise, which change most directly increases oxygen unloading from haemoglobin in active muscle?
- A rise in blood pH
- An increase in carbon dioxide partial pressure Correct answer.
- A decrease in diphosphoglycerate
- A fall in temperature
Explanation
Rising carbon dioxide lowers pH and increases the Bohr effect, shifting the oxyhaemoglobin dissociation curve to the right and releasing more oxygen to tissue. Alkalosis, cooling and reduced diphosphoglycerate all shift the curve left and favour retention of oxygen.
Question 11Anatomy and Physiology
Which mechanism best explains how the sinoatrial node sets the resting heart rate?
- It receives tonic motor input from the vagus nerve
- It is driven by stretch of the ventricular wall
- It generates spontaneous depolarisation through a slow inward current Correct answer.
- It fires only when stimulated by circulating adrenaline
Explanation
Sinoatrial pacemaker cells show spontaneous phase-four depolarisation, driven largely by a slow inward current, which brings the membrane to threshold without external stimulation. Autonomic nerves and catecholamines modulate this rate rather than creating it.
Question 12Anatomy and Physiology
A drug blocks sodium channels in the thick ascending limb of the loop of Henle. Which effect on urine concentration is most likely?
- Reduced ability to concentrate urine Correct answer.
- Increased medullary interstitial osmolarity
- Increased urea recycling in the medulla
- Increased water reabsorption in the collecting duct
Explanation
The thick ascending limb uses sodium-potassium-chloride cotransport to build the medullary osmotic gradient that underpins urine concentration. Blocking these channels reduces the gradient and impairs the kidney's ability to concentrate urine.
Question 13Anatomy and Physiology
Which factor most increases resistance to airflow in a bronchus?
- A decrease in surface tension
- An increase in tidal volume
- An increase in lung compliance
- A decrease in airway radius Correct answer.
Explanation
According to Poiseuille's law, resistance varies inversely with the fourth power of radius, so even small narrowing markedly raises airflow resistance. Compliance, surface tension and tidal volume affect ventilation in other ways.
Question 14Anatomy and Physiology
Which sequence correctly describes the pathway of a red blood cell from the right atrium to the aorta?
- Right atrium, right ventricle, aorta, lungs, pulmonary artery, left atrium, left ventricle
- Right atrium, left atrium, right ventricle, lungs, left ventricle, pulmonary artery, aorta
- Right atrium, right ventricle, pulmonary vein, lungs, pulmonary artery, left atrium, left ventricle, aorta
- Right atrium, right ventricle, pulmonary artery, lungs, pulmonary vein, left atrium, left ventricle, aorta Correct answer.
Explanation
Venous blood enters the right atrium, passes to the right ventricle and is ejected through the pulmonary artery to the lungs. Oxygenated blood returns via pulmonary veins to the left atrium and left ventricle, which pumps it into the aorta.
Question 15Anatomy and Physiology
Which change occurs at the neuromuscular junction when acetylcholinesterase is inhibited?
- Decreased release of acetylcholine
- Prolonged depolarisation of the muscle fibre Correct answer.
- Reduced calcium entry into the axon terminal
- Blockade of postsynaptic acetylcholine receptors
Explanation
Acetylcholinesterase normally breaks down acetylcholine to terminate signalling. Inhibiting it leaves acetylcholine in the synaptic cleft, extending receptor activation and prolonging depolarisation of the muscle fibre.
Question 16Anatomy and Physiology
Which hormone is the principal regulator of calcium concentration in the blood?
- Parathyroid hormone Correct answer.
- Cortisol
- Aldosterone
- Insulin
Explanation
Parathyroid hormone raises blood calcium by stimulating bone resorption, renal calcium reabsorption and activation of vitamin D. The other hormones listed regulate sodium balance, glucose and general metabolism.
Question 17Anatomy and Physiology
In a capillary bed, which force primarily drives fluid filtration at the arteriolar end?
- Interstitial osmotic pressure
- Lymphatic pumping pressure
- Capillary hydrostatic pressure Correct answer.
- Plasma oncotic pressure
Explanation
At the arteriolar end, capillary hydrostatic pressure exceeds the opposing forces, so fluid is filtered into the interstitium. Plasma oncotic pressure and interstitial osmotic pressure oppose filtration, and lymphatic pressure is irrelevant to capillary exchange.
Question 18Anatomy and Physiology
Which structure of the small intestine most increases its absorptive surface area?
- The haustra
- The rugae
- The taeniae coli
- The villi and microvilli Correct answer.
Explanation
Villi and their apical microvilli greatly amplify the mucosal surface for absorption. Haustra, rugae and taeniae coli are features of the large intestine or stomach and do not serve this purpose.
Question 19Anatomy and Physiology
Which event occurs during the plateau phase of a ventricular action potential?
- Chloride efflux
- Balanced calcium influx and potassium efflux Correct answer.
- Rapid potassium influx
- Rapid sodium influx
Explanation
The plateau results from slow calcium entry through L-type channels balanced by potassium efflux, prolonging the action potential and the refractory period. Rapid sodium influx characterises the initial upstroke, not the plateau.
Question 20Anatomy and Physiology
A patient cannot abduct the arm at the shoulder but has normal deltoid bulk. Which nerve lesion is most consistent with this finding?
- The axillary nerve Correct answer.
- The musculocutaneous nerve
- The median nerve
- The radial nerve
Explanation
The axillary nerve supplies the deltoid, which abducts the arm, and it also carries sensation from the shoulder region. Preservation of bulk suggests early or partial involvement, but the functional deficit still localises to this nerve.
Question 21Anatomy and Physiology
Which change in the alveolus would most reduce the work required to inflate the lung?
- Increased airway mucus
- Decreased lung compliance
- Increased surfactant secretion Correct answer.
- Increased alveolar surface tension
Explanation
Surfactant lowers alveolar surface tension, reducing the pressure needed to expand the alveoli and preventing collapse at end-expiration. The other changes all increase the effort of breathing.
Question 22Anatomy and Physiology
A lesion of the dorsal columns of the spinal cord at the thoracic level would impair which sensory modality?
- Fine touch and vibration sense Correct answer.
- Pain and temperature sensation
- Voluntary motor control
- Sympathetic sweating
Explanation
The dorsal columns carry proprioceptive and discriminative touch information, including vibration, which travels in the medial lemniscus pathway. Pain and temperature travel in the spinothalamic tract, and motor and autonomic functions use other pathways.
Question 23Anatomy and Physiology
Which combination best explains why cardiac muscle cannot undergo tetanic contraction?
- Absence of T-tubules and sparse mitochondria
- Long refractory period and gap junction coupling Correct answer.
- Lack of actin and myosin filaments
- Short refractory period and motor unit recruitment
Explanation
The prolonged plateau of the ventricular action potential creates a long refractory period that prevents summation of contractions. Gap junctions allow the myocardium to behave as a functional syncytium, further coordinating contraction.
Question 24Anatomy and Physiology
A patient with a tumour secreting excessive antidiuretic hormone would be expected to show which pattern?
- Hypercalcaemia with renal stones
- Hyperkalaemia with metabolic acidosis
- Hypernatraemia with dilute urine
- Hyponatraemia with concentrated urine Correct answer.
Explanation
Excess antidiuretic hormone increases water reabsorption in the collecting duct, diluting plasma sodium while producing small volumes of concentrated urine. The other patterns reflect different hormonal or renal disturbances.
Question 25Anatomy and Physiology
Which mechanism best explains the Frank-Starling relationship in the intact heart?
- Sympathetic stimulation decreases calcium entry
- Reduced venous return increases stroke volume
- Increased afterload reduces myocardial oxygen demand
- Increased end-diastolic volume stretches sarcomeres and enhances contraction Correct answer.
Explanation
Greater end-diastolic filling stretches myocardial sarcomeres toward an optimal length, increasing calcium sensitivity and cross-bridge formation, which raises stroke volume. Afterload and venous return act differently, and sympathetic stimulation increases rather than reduces calcium entry.
Question 26Anatomy and Physiology
Which type of cartilage forms the articular surface of a synovial joint such as the knee?
- Fibrocartilage
- Hyaline cartilage Correct answer.
- Calcified cartilage
- Elastic cartilage
Explanation
Articular surfaces of synovial joints are lined by hyaline cartilage, which provides a smooth, low-friction interface and distributes compressive load. Its sparse chondrocytes and high water content allow it to withstand repeated loading, though it has limited intrinsic repair capacity.
Question 27Anatomy and Physiology
Which blood vessel type has the thinnest wall relative to its lumen and contains valves along its length?
- Aorta
- Arteriole
- Medium vein Correct answer.
- Muscular artery
Explanation
Veins have thin walls relative to their wide lumens and low-pressure flow, so medium and large veins contain intimal valves that prevent backflow toward the capillaries. Arteries have thicker muscular and elastic walls and no such valves.
Question 28Anatomy and Physiology
Which plasma protein is most responsible for maintaining the colloid osmotic pressure of blood?
- Prothrombin
- Albumin Correct answer.
- Immunoglobulin G
- Fibrinogen
Explanation
Albumin is the most abundant plasma protein and, because of its relatively small size and high concentration, contributes most of the plasma colloid osmotic (oncotic) pressure that holds fluid within capillaries. Fibrinogen and globulins contribute far less to oncotic pressure.
Question 29Anatomy and Physiology
Which structure connects the right ventricle to the pulmonary trunk?
- Tricuspid valve
- Aortic valve
- Pulmonary valve Correct answer.
- Mitral valve
Explanation
The pulmonary valve is a semilunar valve at the junction of the right ventricular outflow tract and the pulmonary trunk, preventing backflow into the ventricle during diastole. The other named valves guard the aortic root or the atrioventricular openings.
Question 30Anatomy and Physiology
A patient's spirometry shows a reduced forced expiratory volume in one second (FEV1) with a normal or increased forced vital capacity and a reduced FEV1/FVC ratio. Which pattern does this indicate?
- Obstructive ventilatory defect Correct answer.
- Restrictive ventilatory defect
- Normal ventilatory function
- Isolated diffusion impairment
Explanation
A reduced FEV1/FVC ratio indicates airflow obstruction, because the volume expired in the first second falls disproportionately to total expired volume. Restrictive disease instead reduces FVC with a preserved or raised ratio, and diffusion impairment does not by itself alter spirometric volumes.
Question 31Anatomy and Physiology
Which part of the brain contains the primary somatosensory cortex that receives input from the dorsal column-medial lemniscus pathway?
- Precentral gyrus of the frontal lobe
- Uncus of the temporal lobe
- Calcarine sulcus of the occipital lobe
- Postcentral gyrus of the parietal lobe Correct answer.
Explanation
Dorsal column-medial lemniscus fibres relay in the thalamus and project to the primary somatosensory cortex on the postcentral gyrus of the parietal lobe. This cortex is organised somatotopically and processes discriminative touch and proprioception.
Question 32Anatomy and Physiology
During the cardiac cycle, which event corresponds to the first heart sound?
- Closure of the semilunar valves at the start of diastole
- Closure of the atrioventricular valves at the start of ventricular systole Correct answer.
- Opening of the atrioventricular valves during rapid filling
- Atrial contraction at the end of diastole
Explanation
The first heart sound arises when the mitral and tricuspid valves close as ventricular pressure exceeds atrial pressure at the onset of systole. The second sound instead reflects semilunar valve closure at the end of systole.
Question 33Anatomy and Physiology
A patient has a raised haematocrit and increased blood viscosity from polycythaemia. According to Poiseuille's relationship, which change in vascular resistance is expected if vessel geometry is unchanged?
- Resistance is unaffected by viscosity
- Resistance increases in proportion to viscosity Correct answer.
- Resistance falls with the square of viscosity
- Resistance decreases in proportion to viscosity
Explanation
In Poiseuille's equation, resistance is directly proportional to fluid viscosity when vessel length and radius are constant. A rise in haematocrit therefore raises viscosity and increases resistance, which tends to increase cardiac workload.
Question 34Anatomy and Physiology
Which mechanism generates the resting membrane potential of a typical neuron?
- Complete impermeability of the membrane to all ions
- Selective potassium permeability combined with the electrogenic sodium-potassium pump Correct answer.
- Equal permeability of the membrane to sodium and potassium ions
- Rapid influx of calcium through voltage-gated channels
Explanation
At rest the membrane is far more permeable to potassium than to sodium, so potassium efflux drives the interior negative. The sodium-potassium ATPase contributes an additional small electrogenic effect by exporting three sodium ions for every two potassium ions imported.
Question 35Anatomy and Physiology
Which change would most increase the glomerular filtration rate in a person with unchanged systemic arterial pressure?
- Dilation of the afferent arteriole with unchanged efferent tone
- A rise in plasma protein concentration
- Constriction of the efferent arteriole with unchanged afferent tone Correct answer.
- Constriction of the afferent arteriole
Explanation
Efferent arteriolar constriction raises glomerular capillary hydrostatic pressure and therefore tends to increase filtration, provided renal blood flow is not critically reduced. Afferent dilation also raises pressure, but the option pairing dilation with unchanged efferent tone is the weaker of the two relative to the standard effect of efferent constriction.
Question 36Anatomy and Physiology
Which lung volume cannot be measured by simple spirometry and requires techniques such as helium dilution or body plethysmography?
- Inspiratory reserve volume
- Expiratory reserve volume
- Residual volume Correct answer.
- Tidal volume
Explanation
Residual volume is the air remaining in the lungs after maximal expiration and cannot be exhaled into a spirometer. It is therefore determined indirectly, for example by helium dilution or plethysmography, whereas the other listed volumes are directly measurable.
Question 37Anatomy and Physiology
Which mechanism best explains the increase in ventilation during metabolic acidosis?
- Inhibition of medullary respiratory neurons by bicarbonate
- Direct stimulation of the diaphragm by hydrogen ions in arterial blood
- Stimulation of central chemoreceptors by hydrogen ions generated from carbon dioxide in cerebrospinal fluid Correct answer.
- Stimulation of carotid bodies by reduced arterial oxygen content
Explanation
Hydrogen ions cross the blood-brain barrier poorly, but carbon dioxide diffuses freely into cerebrospinal fluid, where it forms carbonic acid and releases hydrogen ions that stimulate central chemoreceptors. This drives increased ventilation to lower arterial carbon dioxide and compensate for the metabolic acidosis.
Question 38Anatomy and Physiology
A patient sustains damage to the right phrenic nerve in the neck. Which consequence is most likely?
- Paralysis of the right hemidiaphragm with reduced inspiratory capacity Correct answer.
- Loss of sensation over the right shoulder
- Weakness of the right intercostal muscles
- Inability to abduct the right arm
Explanation
The phrenic nerve (C3-C5) provides the sole motor supply to the diaphragm, so a right-sided lesion paralyses the right hemidiaphragm and reduces inspiratory capacity. Intercostal muscles are supplied by segmental intercostal nerves, and shoulder and arm muscles have different innervation.
Question 39Anatomy and Physiology
A patient is given a drug that inhibits the sodium-potassium ATPase of skeletal muscle fibres. Which immediate consequence is most likely at the muscle membrane?
- Immediate loss of the action potential upstroke
- Hyperpolarisation as intracellular sodium falls
- No change because the pump is electrically neutral
- Depolarisation of the membrane as intracellular potassium rises Correct answer.
Explanation
The sodium-potassium ATPase normally exports three sodium ions for every two potassium ions imported, helping keep the interior negative. Inhibiting it allows intracellular sodium to rise and potassium to fall, dissipating the gradients and producing depolarisation, which can eventually inactivate sodium channels.
Question 40Anatomy and Physiology
A tumour of the adrenal cortex secretes excessive aldosterone. Which set of changes is most consistent with primary hyperaldosteronism?
- Hypotension with hyperkalaemia and metabolic acidosis
- Hypertension with hypokalaemia and metabolic alkalosis Correct answer.
- Hypertension with hyperkalaemia and metabolic acidosis
- Hypotension with hypokalaemia and respiratory alkalosis
Explanation
Aldosterone increases sodium reabsorption and potassium secretion in the distal nephron, expanding extracellular volume and raising blood pressure while lowering plasma potassium. The resulting loss of hydrogen ions and shift of hydrogen into cells produces a metabolic alkalosis.
Question 41Microbiology and Infection Control
A nurse is preparing to care for a patient with an active pulmonary tuberculosis infection. Which type of transmission precaution is required in addition to standard precautions?
- Droplet precautions
- Contact precautions
- Protective isolation
- Airborne precautions Correct answer.
Explanation
Tuberculosis spreads through airborne droplet nuclei that remain suspended in the air and travel on air currents, so an airborne infection isolation room with negative pressure and a fitted respirator is required. Standard precautions alone do not block these small particles.
Question 42Microbiology and Infection Control
A phlebotomist is about to perform a venipuncture and has just used an alcohol-based hand rub. Which action is appropriate immediately before donning clean gloves?
- Allow the hands to dry completely first Correct answer.
- Blot the hands dry with a paper towel
- Rinse the hands under running water
- Apply the gloves while the hands are still wet
Explanation
Alcohol-based hand rub must be rubbed into the hands until they feel dry; the friction and evaporation time are part of the antimicrobial action. Wiping off the product or adding water reduces its effectiveness.
Question 43Microbiology and Infection Control
Which statement correctly describes the normal flora of the human body?
- Resident microbiota are found in sterile sites such as blood and cerebrospinal fluid
- Normal flora are always eliminated by a single course of antibiotics
- Normal flora provide no protective function against invading organisms
- Resident microbiota colonize body surfaces and can become opportunistic pathogens Correct answer.
Explanation
Resident microbiota live harmlessly on skin and mucosa but can cause infection when barriers break or immunity falls, a classic opportunistic pattern. They also compete with pathogens for nutrients and attachment sites, providing colonization resistance.
Question 44Microbiology and Infection Control
A patient is diagnosed with scabies. Which precaution is indicated until treatment has been completed?
- Airborne precautions
- No additional precautions
- Contact precautions Correct answer.
- Droplet precautions
Explanation
Scabies mites spread through prolonged skin-to-skin contact and contaminated bedding or clothing, so contact precautions with thorough environmental cleaning are required. Airborne and droplet routes are not relevant to this infestation.
Question 45Microbiology and Infection Control
A healthcare worker sustains a needlestick injury from a hollow-bore needle. Which action should be taken first?
- Squeeze the wound to express blood
- Wash the wound with soap and running water Correct answer.
- Wait for the source patient's test results before any action
- Apply a tight tourniquet above the site
Explanation
Immediate washing with soap and water reduces contamination at the site and is the first step after a percutaneous exposure. Post-exposure prophylaxis and source evaluation follow promptly but do not delay wound care.
Question 46Microbiology and Infection Control
Which structure allows certain bacteria to survive harsh conditions such as heat and desiccation by forming a dormant, highly resistant cell?
- Capsule
- Flagellum
- Endospore Correct answer.
- Pilus
Explanation
Endospores are dormant forms produced by genera such as Bacillus and Clostridium that resist heat, drying, and many disinfectants. Their resistance makes sterilization standards such as autoclaving necessary.
Question 47Microbiology and Infection Control
Which practice best prevents catheter-associated urinary tract infections in a patient with an indwelling urinary catheter?
- Changing the catheter every 24 hours regardless of need
- Irrigating the catheter routinely with saline
- Maintaining a closed drainage system below bladder level Correct answer.
- Disconnecting the tubing to collect urine samples daily
Explanation
A closed system with the drainage bag kept below the bladder prevents urine backflow and reduces the entry of organisms. Routine irrigation, frequent disconnection, and unnecessary exchanges all introduce pathogens.
Question 48Microbiology and Infection Control
Which term describes an infection acquired by a patient during hospitalization that was not present or incubating at the time of admission?
- Opportunistic infection
- Subclinical infection
- Community-acquired infection
- Healthcare-associated infection Correct answer.
Explanation
A healthcare-associated infection arises as a result of care in a healthcare setting and was neither present nor incubating on admission. Surveillance definitions often use timeframes such as 48 hours after admission for identification.
Question 49Microbiology and Infection Control
A nurse is removing a pair of soiled gloves after patient care. Which sequence correctly describes safe glove removal?
- Remove gloves, then touch the patient's bed rails before performing hand hygiene
- Pull both gloves off by the fingertips simultaneously
- Blow into the gloves to loosen them before removal
- Grasp the outside of one glove, peel it off, then remove the second glove by the inside surface Correct answer.
Explanation
Removing the first glove by its outside and the second by slipping fingers under the inside cuff keeps bare hands away from contaminated surfaces. Hand hygiene follows immediately after removal.
Question 50Microbiology and Infection Control
A patient with Clostridioides difficile infection has frequent diarrhea. Which hand hygiene method should staff use after contact with the patient or the environment?
- Use an alcohol-based hand rub alone
- Use an alcohol-based hand rub followed by a water rinse
- Wash with soap and water Correct answer.
- Use antiseptic wipes on the hands
Explanation
C. difficile spores are not reliably killed by alcohol, so mechanical washing with soap and water is preferred to remove spores physically. Alcohol rub may be used only when hands are not visibly soiled and soap and water are unavailable.