MRCPI GM Part I study plan

Derive sensitivity, specificity, predictive values and likelihood ratios from a 2x2 table, and recalculate them after changing disease prevalence

Calculate and interpret absolute risk reduction, relative risk, odds ratio, NNT and 95% confidence intervals for cohort, case-control and trial designs

Apply volume of distribution, clearance, half-life and bioavailability to construct loading and maintenance doses and to predict accumulation and washout

Solve pharmacokinetic and pharmacodynamic problems involving zero-order kinetics, protein binding and enzyme inhibition or induction

Explain core genetic and immunological mechanisms (inheritance patterns, enzyme deficiencies, complement and immunoglobulin function) using exam-style vignettes

Classify acute coronary syndromes and justify a reperfusion strategy against time from symptom onset, ECG findings and bleeding risk

Interpret 30 ECG recordings covering arrhythmia, conduction block, ischaemia, hypertrophy and electrolyte change without reference to the answer key

Match heart failure therapy to ejection fraction category and symptom class, and apply device and anticoagulation indications

Grade asthma and COPD severity and select inhaler, oxygen and non-invasive ventilation strategy for each grade

Interpret arterial blood gases and spirometry to separate obstructive from restrictive physiology and to identify the dominant acid-base disorder

Calculate and correct sodium, potassium, calcium and magnesium disorders using a stepwise framework that includes anion gap and delta gap

Use urine osmolality, urine sodium and fractional excretion of sodium to classify acute kidney injury and hyponatraemia

Construct and adjust insulin regimens and oral hypoglycaemic therapy, matching each drug class to mechanism, monitoring requirement and key adverse effect

Diagnose thyroid, adrenal and pituitary disease from paired hormone results, and identify the confirmatory dynamic test for each

Complete 50 single-best-answer items on electrolytes and endocrinology with at least 75% accuracy

Apply Child-Pugh, MELD, Glasgow-Blatchford and Rockall scores to grade severity and set the level of care in liver and gastrointestinal bleeding vignettes

Differentiate cholestatic from hepatocellular liver injury patterns and select the targeted serology or imaging that confirms each cause

Classify anaemia by reticulocyte count and red cell indices, and name the single confirmatory test for each category

Interpret full blood count and coagulation screen combinations to reach a haematological diagnosis in 25 vignettes

Outline immediate management of neutropenic sepsis, hyperviscosity, tumour lysis and suspected thrombotic microangiopathy

Localise neurological lesions to upper or lower motor neuron, cranial nerve, spinal level or peripheral nerve from described examination findings

Distinguish stroke subtypes and apply thrombolysis and thrombectomy eligibility criteria including time window and contraindications

Classify seizure type and select antiseptic therapy appropriate to patient group, comorbidity and teratogenic risk

Interpret synovial fluid analysis and autoantibody panels to classify inflammatory, crystal and septic arthritis

Apply a treat-to-target approach to rheumatoid arthritis and screen systematically for extra-articular disease and drug toxicity

Select empirical antimicrobial therapy by site, severity of sepsis and resistance risk, then de-escalate or narrow once culture and sensitivity results return

Apply notification, isolation and post-exposure rules to common healthcare-associated and imported infections

Screen older adults using validated instruments (4AT or AMT, falls risk, Clinical Frailty Scale, Barthel index) and act on abnormal scores

Reduce polypharmacy by applying STOPP/START criteria to 10 medication lists and justify each withdrawal or addition

Recognise atypical presentations of acute illness in older adults and apply the components of comprehensive geriatric assessment

Re-attempt every item missed in weeks 1 to 6 on fluid, electrolyte and endocrine topics and record the corrected reasoning for each

Redo acid-base and sodium correction calculations until each is completed correctly in under 90 seconds

Convert weak sub-topics identified in week 4 into 30 new self-written single-best-answer questions with a defensible single correct answer

Integrate biochemical and endocrine data interpretation into full clinical vignettes rather than isolated values

Sit two full-length timed mock papers of 100 items each under exam conditions and record the score for every domain separately

Interpret study abstracts, forest plots and screening statistics under time pressure to confirm that domain 12 reasoning is automated rather than deliberated

Consolidate the highest-yield facts across all domains into a single revision sheet limited to content that has repeatedly caused errors

Rehearse timing and question triage so that no item is left unanswered in either mock