NAPLEX study materials
NAPLEX study resources

NAPLEX study plan

NAPLEX · Give each week a clear focus.

8 weeks · About 8 hours per week

Week 1

Pharmacotherapy and Pharmaceutical Care

  • Build a one-page disease-state map for hypertension, heart failure, and dyslipidemia linking guideline-directed drug classes to patient-specific selection criteria

  • Draft patient-specific treatment algorithms for type 2 diabetes that sequence agents by comorbidity, cost, and hypoglycemia risk

  • Compare anticoagulant options (warfarin, DOACs, heparin products) by indication, monitoring parameter, and reversal strategy

  • Explain the mechanism, monitoring, and counseling points for the 25 highest-yield cardiovascular drugs without referring to notes

Your checkpoint

A 120-question untimed Domain 1 quiz on cardiovascular and endocrine topics scored at 70% or higher, with every missed item rewritten as a corrected one-line clinical pearl

Week 2

Pharmacotherapy and Pharmaceutical Care

  • Select empiric antibiotic regimens for pneumonia, urinary tract infection, skin infection, and sepsis using local resistance patterns and patient allergy history

  • Distinguish bacterial, viral, and fungal respiratory presentations and justify when antimicrobial therapy should be withheld

  • Construct monitoring plans for patients on vancomycin, aminoglycosides, and other narrow-therapeutic-index antimicrobials

  • Apply guideline-based step therapy for asthma and COPD, including inhaler technique and device selection

Your checkpoint

A completed 40-case infectious disease and respiratory case set with documented drug regimen, dose rationale, and monitoring parameter for each case

Week 3

Pharmacotherapy and Pharmaceutical Care & Pharmacy Calculations and Compounding

  • Design titration and monitoring plans for antidepressants, antipsychotics, and mood stabilizers, including black-box warnings to counsel on

  • Formulate opioid and non-opioid analgesic regimens with equianalgesic conversions, naloxone co-prescribing criteria, and bowel regimen prophylaxis

  • Solve weight-based, renal-adjusted, and body-surface-area dosing problems accurately under timed conditions

  • Verify prescription calculations for pediatric and geriatric patients using dimensional analysis

Your checkpoint

A 30-item timed calculations set (mixed concentration, dose conversion, renal adjustment, and infusion rate problems) completed with 90% accuracy in under 30 minutes

Week 4

Pharmacotherapy and Pharmaceutical Care & Pharmacy Calculations and Compounding

  • Integrate therapeutic knowledge across GI, renal, and hematologic disorders by resolving 50 cross-domain case vignettes

  • Perform alligation, dilution, and ratio strength calculations and isotonicity adjustments without a reference

  • Interpret creatinine clearance, hepatic function, and drug-interaction data to justify a dose adjustment in patient cases

  • Identify and correct unsafe prescriptions by spotting dose, frequency, and interaction errors

Your checkpoint

A scored 100-question cumulative assessment weighted to Domain 1, with a written remediation list of the three weakest therapeutic areas and a study action for each

Week 5

Foundations of Pharmacy Practice

  • Map the pharmacology, mechanism, and class effects of major drug families to their adverse effect profiles and contraindications

  • Explain pharmacokinetic principles (absorption, distribution, metabolism, elimination, half-life, steady state) and apply them to dosing interval decisions

  • Predict clinically significant drug interactions using CYP450 and transporter knowledge and rank them by severity

  • Relate dosage-form design, excipients, and routes of administration to bioavailability and patient counseling points

Your checkpoint

A self-built 60-row drug-class summary table (class, mechanism, key adverse effects, counseling point) completed from memory and corrected against references to at least 95% accuracy

Week 6

Pharmacy Calculations and Compounding & Regulatory, Legal, and Professional Standards

  • Perform sterile and nonsterile compounding calculations including percentage strength, milliequivalents, and beyond-use dating determination

  • Apply USP chapter standards for sterile compounding, hazardous drug handling, and prescription labeling requirements

  • Differentiate the legal requirements for controlled substance schedules, refills, and partial fills under federal law

  • Outline pharmacist duties for error reporting, REMS participation, and prescription transfer rules

Your checkpoint

A 25-question regulatory and compounding mixed quiz scored at 80% or higher plus a one-page compounding calculation cheat sheet verified against USP standards

Week 7

Drug Distribution and Inventory Management & Patient Counseling and Communication

  • Explain inventory control methods, formulary decision-making, and drug shortage mitigation strategies used in pharmacy practice

  • Describe the drug distribution pathways for unit dose, automated dispensing, and controlled substance accountability

  • Deliver motivational-interviewing-based counseling scripts for new prescriptions, inhalers, injectables, and adherence barriers

  • Adapt communication for low health literacy, interpreter needs, and caregiver involvement using teach-back

Your checkpoint

Three recorded or scripted counseling sessions (10 minutes each) scored against a teach-back and health-literacy rubric by a peer or preceptor with at least 80% checklist completion

Week 8

Pharmacotherapy and Pharmaceutical Care & Foundations of Pharmacy Practice & Patient Counseling and Communication

  • Complete two full-length timed mixed-domain practice exams under test-day conditions

  • Audit missed questions by domain and root cause (knowledge gap, misread, calculation error) and rank the top five recurring weaknesses

  • Re-drill the highest-yield weak areas using spaced retrieval until recall is fluent

  • Rehearse a final-week schedule that balances high-yield review with rest and a timed warm-up set

Your checkpoint

Two full-length practice exams scored at 75% or higher overall with no single domain below 65%, and a finalized one-page pre-exam review sheet

Milestones