NAPLEX study plan
NAPLEX · Give each week a clear focus.
8 weeks · About 8 hours per week
Pharmacotherapy and Pharmaceutical Care
Build a one-page disease-state map for hypertension, heart failure, and dyslipidemia linking guideline-directed drug classes to patient-specific selection criteria
Draft patient-specific treatment algorithms for type 2 diabetes that sequence agents by comorbidity, cost, and hypoglycemia risk
Compare anticoagulant options (warfarin, DOACs, heparin products) by indication, monitoring parameter, and reversal strategy
Explain the mechanism, monitoring, and counseling points for the 25 highest-yield cardiovascular drugs without referring to notes
Your checkpoint
A 120-question untimed Domain 1 quiz on cardiovascular and endocrine topics scored at 70% or higher, with every missed item rewritten as a corrected one-line clinical pearl
Pharmacotherapy and Pharmaceutical Care
Select empiric antibiotic regimens for pneumonia, urinary tract infection, skin infection, and sepsis using local resistance patterns and patient allergy history
Distinguish bacterial, viral, and fungal respiratory presentations and justify when antimicrobial therapy should be withheld
Construct monitoring plans for patients on vancomycin, aminoglycosides, and other narrow-therapeutic-index antimicrobials
Apply guideline-based step therapy for asthma and COPD, including inhaler technique and device selection
Your checkpoint
A completed 40-case infectious disease and respiratory case set with documented drug regimen, dose rationale, and monitoring parameter for each case
Pharmacotherapy and Pharmaceutical Care & Pharmacy Calculations and Compounding
Design titration and monitoring plans for antidepressants, antipsychotics, and mood stabilizers, including black-box warnings to counsel on
Formulate opioid and non-opioid analgesic regimens with equianalgesic conversions, naloxone co-prescribing criteria, and bowel regimen prophylaxis
Solve weight-based, renal-adjusted, and body-surface-area dosing problems accurately under timed conditions
Verify prescription calculations for pediatric and geriatric patients using dimensional analysis
Your checkpoint
A 30-item timed calculations set (mixed concentration, dose conversion, renal adjustment, and infusion rate problems) completed with 90% accuracy in under 30 minutes
Pharmacotherapy and Pharmaceutical Care & Pharmacy Calculations and Compounding
Integrate therapeutic knowledge across GI, renal, and hematologic disorders by resolving 50 cross-domain case vignettes
Perform alligation, dilution, and ratio strength calculations and isotonicity adjustments without a reference
Interpret creatinine clearance, hepatic function, and drug-interaction data to justify a dose adjustment in patient cases
Identify and correct unsafe prescriptions by spotting dose, frequency, and interaction errors
Your checkpoint
A scored 100-question cumulative assessment weighted to Domain 1, with a written remediation list of the three weakest therapeutic areas and a study action for each
Foundations of Pharmacy Practice
Map the pharmacology, mechanism, and class effects of major drug families to their adverse effect profiles and contraindications
Explain pharmacokinetic principles (absorption, distribution, metabolism, elimination, half-life, steady state) and apply them to dosing interval decisions
Predict clinically significant drug interactions using CYP450 and transporter knowledge and rank them by severity
Relate dosage-form design, excipients, and routes of administration to bioavailability and patient counseling points
Your checkpoint
A self-built 60-row drug-class summary table (class, mechanism, key adverse effects, counseling point) completed from memory and corrected against references to at least 95% accuracy
Pharmacy Calculations and Compounding & Regulatory, Legal, and Professional Standards
Perform sterile and nonsterile compounding calculations including percentage strength, milliequivalents, and beyond-use dating determination
Apply USP chapter standards for sterile compounding, hazardous drug handling, and prescription labeling requirements
Differentiate the legal requirements for controlled substance schedules, refills, and partial fills under federal law
Outline pharmacist duties for error reporting, REMS participation, and prescription transfer rules
Your checkpoint
A 25-question regulatory and compounding mixed quiz scored at 80% or higher plus a one-page compounding calculation cheat sheet verified against USP standards
Drug Distribution and Inventory Management & Patient Counseling and Communication
Explain inventory control methods, formulary decision-making, and drug shortage mitigation strategies used in pharmacy practice
Describe the drug distribution pathways for unit dose, automated dispensing, and controlled substance accountability
Deliver motivational-interviewing-based counseling scripts for new prescriptions, inhalers, injectables, and adherence barriers
Adapt communication for low health literacy, interpreter needs, and caregiver involvement using teach-back
Your checkpoint
Three recorded or scripted counseling sessions (10 minutes each) scored against a teach-back and health-literacy rubric by a peer or preceptor with at least 80% checklist completion
Pharmacotherapy and Pharmaceutical Care & Foundations of Pharmacy Practice & Patient Counseling and Communication
Complete two full-length timed mixed-domain practice exams under test-day conditions
Audit missed questions by domain and root cause (knowledge gap, misread, calculation error) and rank the top five recurring weaknesses
Re-drill the highest-yield weak areas using spaced retrieval until recall is fluent
Rehearse a final-week schedule that balances high-yield review with rest and a timed warm-up set
Your checkpoint
Two full-length practice exams scored at 75% or higher overall with no single domain below 65%, and a finalized one-page pre-exam review sheet