NPC B.Pharm study plan

Map the Domain 2 syllabus into a one-page checklist covering organic pharmaceutical chemistry, inorganic pharmaceutical chemistry, instrumental analysis and titrimetric methods, then tick off every subtopic you can already define.

Draw and label the functional-group interconversions and named reactions most often used in drug synthesis (esterification, amidation, reductive amination, Friedel-Crafts acylation, Hofmann rearrangement) and write the reagent and one medicinal example for each.

Derive the calibration curve mathematics for UV-Vis spectrophotometry (Beer-Lambert law, molar absorptivity, A = εbc) and solve five numerical problems on concentration, dilution and assay percentage without looking at a formula sheet.

Explain the difference between accuracy and precision, and classify the sources of determinate and indeterminate error in a pharmaceutical assay with one concrete laboratory example for each.

Compare the principles, mobile/stationary phase requirements, detector types and typical applications of HPLC, GC, TLC and HPTLC in a single comparison table.

Interpret a set of given spectral data (IR absorption bands, 1H-NMR chemical shifts and splitting, mass spectral molecular ion and fragments) to propose a structure for three small molecules, justifying each assignment.

Perform stoichiometric titration calculations for acid-base, redox, complexometric and non-aqueous titrations, including molarity, normality, equivalence point and percentage purity.

Describe pharmacopoeial quality-control tests (identification, assay, limit tests for chloride, sulphate, iron and heavy metals, dissolution and disintegration) and state why each test exists.

Classify dosage forms by route and physical state, and for each class list the critical quality attributes that must be controlled.

Derive and apply the pharmacokinetic and formulation equations behind sustained-release design (zero-order and first-order release, Higuchi model, dissolution Noyes-Whitney equation) to three numerical scenarios.

Explain the role of excipients (diluents, binders, disintegrants, lubricants, glidants, surfactants, preservatives) and justify an excipient selection for a tablet, a suspension and an emulsion.

Compare tablet manufacturing routes (direct compression, wet granulation, dry granulation) and identify the defects each route is prone to and how to prevent them.

Explain the design, working principle and critical operating parameters of the equipment used in solid and liquid manufacture (fluidised bed dryer, rotary tablet press, colloidal mill, homogeniser, autoclave, lyophiliser).

Apply sterilisation science: compare moist heat, dry heat, filtration, radiation and gaseous methods by mechanism, D-value, F0 concept and material suitability.

Evaluate stability testing requirements (stress, accelerated, intermediate and long-term conditions, shelf-life estimation from Arrhenius behaviour) and design a stability protocol for one product.

Describe GMP-relevant facility and environmental controls for sterile and non-sterile manufacture, including cleanroom grades and the meaning of each grade.