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- Alveolar oxygen equation
- PAO2 equals FiO2 times barometric pressure minus 47, minus PaCO2 divided by respiratory quotient, usually 0.8; it estimates alveolar oxygen before diffusion.
- Oxygen content formula
- Arterial oxygen content equals 1.34 times hemoglobin times arterial oxygen saturation plus 0.003 times PaO2; the first term is bound oxygen and the second dissolved oxygen.
- V/Q mismatch extremes
- A shunt has a ventilation-perfusion ratio of zero and does not improve much with supplemental oxygen; dead space has a ratio approaching infinity and wastes ventilation without gas exchange.
- Surfactant function
- Type II alveolar cells secrete surfactant, which lowers surface tension, increases compliance, and helps prevent alveolar collapse and edema at end expiration.
- Oxyhemoglobin curve right shift
- Increased carbon dioxide, hydrogen ion concentration, temperature, and 2,3-BPG shift the oxyhemoglobin curve right, reducing hemoglobin affinity and releasing more oxygen to tissues.
- Cylinder duration formula
- Duration in minutes equals gauge pressure in psi times the cylinder factor divided by gas flow in liters per minute; an E cylinder factor is about 0.28.
- Air entrainment ratio
- For a Venturi device, air-to-oxygen ratio equals 100 minus desired FiO2 divided by desired FiO2 minus 21; total flow equals oxygen flow times one plus that ratio.
- Oropharyngeal airway contraindication
- An oropharyngeal airway is avoided in a conscious or semiconscious patient with an intact gag reflex because it can trigger gagging, vomiting, and aspiration.
- Endotracheal cuff pressure
- Adult endotracheal tube cuff pressure is kept near 20 to 30 cm H2O to seal the airway while limiting pressure injury to the tracheal mucosa.
- Capnography waveform phases
- Phase I is anatomic dead space, phase II is mixing of dead space and alveolar gas, phase III is the alveolar plateau, and phase IV is the inspiratory downstroke.
- Volume-control ventilation
- Volume-control ventilation delivers a set tidal volume at a set rate; peak airway pressure and plateau pressure vary with compliance and resistance.
- Ideal body weight male
- For a male, ideal body weight in kilograms equals 50 plus 2.3 times height in inches minus 60; tidal volume is based on this value.
- ARDS Berlin definition
- ARDS is acute onset hypoxemia with PaO2/FiO2 of 300 or less on PEEP of at least 5 cm H2O, bilateral opacities, and respiratory failure not fully explained by cardiac failure.
- Auto-PEEP cause
- Auto-PEEP occurs when expiration is incomplete, trapping gas and raising end-expiratory alveolar pressure; it can cause hypotension and barotrauma and is reduced by lengthening expiratory time.
- Rapid shallow breathing index
- The rapid shallow breathing index equals respiratory rate divided by tidal volume in liters; a value below 105 predicts a higher likelihood of successful weaning from mechanical ventilation.
- Pulsus paradoxus
- Pulsus paradoxus is an inspiratory fall in systolic blood pressure greater than 10 mm Hg, classically seen in severe asthma, COPD, and cardiac tamponade.
- Mean arterial pressure
- Mean arterial pressure is approximately diastolic pressure plus one third of the pulse pressure, or systolic pressure plus twice diastolic pressure divided by three.
- Glasgow Coma Scale range
- The Glasgow Coma Scale sums eye, verbal, and motor responses for a score of 3 to 15; a lower score indicates a lower level of consciousness.
- Sudden ETCO2 drop
- A sudden fall in end-tidal carbon dioxide may indicate tube disconnection, extubation, esophageal intubation, cardiac arrest, or pulmonary embolism and requires immediate assessment.
- Normal arterial blood gas
- Normal adult arterial values are pH 7.35 to 7.45, PaCO2 35 to 45 mm Hg, bicarbonate 22 to 26 mEq/L, and PaO2 80 to 100 mm Hg.
- Anion gap formula
- The serum anion gap equals sodium minus the sum of chloride and bicarbonate; a normal value is about 8 to 12 mEq/L, and elevation suggests organic acidosis.
- Obstructive spirometry pattern
- Obstruction shows a reduced FEV1/FVC ratio below 0.70, reduced FEV1, and often increased residual volume and total lung capacity from air trapping.
- Bronchodilator response
- A positive bronchodilator response is an increase in FEV1 or FVC of at least 12 percent and at least 200 mL from prebronchodilator values.
- Apnea-hypopnea index
- The apnea-hypopnea index is the number of apneas plus hypopneas per hour of sleep; 5 to 15 is mild, 15 to 30 is moderate, and above 30 is severe.
- Beta2 agonist action
- Beta2 agonists such as albuterol stimulate beta2 receptors, raise cyclic AMP, and relax bronchial smooth muscle; adverse effects include tachycardia, tremor, and hypokalemia.
- Inhaled corticosteroid precaution
- After inhaled corticosteroid use, rinsing the mouth and spitting reduces oropharyngeal candidiasis and dysphonia caused by local drug deposition.
- Aerosol particle size
- Aerosol particles of about 1 to 5 micrometers deposit most effectively in the lower respiratory tract; larger particles impact in the upper airway.
- Theophylline therapeutic range
- Theophylline has a narrow therapeutic serum range of about 5 to 15 micrograms per milliliter; toxicity can cause arrhythmias, seizures, and persistent vomiting.
- Neonatal normal respiratory rate
- A normal newborn respiratory rate is about 30 to 60 breaths per minute; sustained rates above 60 with retractions or grunting suggest respiratory distress.
- Apgar score components
- The Apgar score assesses appearance, pulse, grimace, activity, and respiration at 1 and 5 minutes; each component scores 0 to 2 for a total of 10.
- Neonatal chest compression ratio
- In neonatal resuscitation, chest compressions are given at a ratio of 3 compressions to 1 breath when the heart rate remains below 60 per minute after effective ventilation.
- Pediatric uncuffed tube size
- For a child older than 1 year, uncuffed endotracheal tube internal diameter in millimeters equals age in years divided by 4 plus 4.