PTCB Immunization study materials
PTCB Immunization study resources

PTCB Immunization cheat sheet

PTCB Immunization · Keep the key ideas within reach.

Quick reference

Immunization Administration

  • Intramuscular injections for adults and older children go into the deltoid; needle length 1 to 1.5 inches (25-38 mm) with gauge 22-25 for most vaccines.

  • Subcutaneous injections use a 23-25 gauge needle, 5/8 inch long, at a 45-degree angle into fatty tissue such as the upper-outer triceps.

  • Intradermal injections use a 26-27 gauge needle, 3/8 inch long, at a 5-15 degree angle; a visible wheal confirms correct placement.

  • Infants and toddlers receive IM vaccines in the vastus lateralis; the deltoid is preferred from about age 3 years and older.

  • For IM injections, stretch the skin flat (not pinched) in adults; in infants and small children, bunch the tissue before injecting.

  • Aspiration before injection is not recommended for any vaccine; inject the full dose and withdraw the needle at the same angle.

  • Separate two injectable vaccines at the same visit by at least 1 inch (2.5 cm) when possible, and use separate syringes and sites.

  • A 5/8 inch needle is adequate for SC injection; a 1 inch needle may be used for IM in the deltoid of adults weighing under 60 kg.

Quick reference

Vaccine Storage and Handling

  • Refrigerated vaccines are stored at 2 to 8 degrees C (36 to 46 degrees F); frozen vaccines at -50 to -15 degrees C (-58 to +5 degrees F).

  • Store vaccines in the middle of the refrigerator, away from walls, floor, and cold-air vents, to avoid freezing or heat exposure.

  • Use a calibrated digital data logger with a buffered probe placed among the vaccines to monitor temperature continuously.

  • Record minimum and maximum temperatures at least twice each workday, at the start and end of the day.

  • A temperature excursion requires labeling the affected vaccine DO NOT USE, quarantining it, and contacting the manufacturer or immunization program for viability guidance.

  • Never store food or specimens in a vaccine refrigerator; keep water bottles in the door to buffer temperature swings, not in the vaccine compartment.

  • Vaccines must never be stored in a freezer door or on a freezer shelf; place them in the central portion of the freezer unit.

  • Rotate stock using first-expiry, first-out; check expiration dates monthly and remove expired product from usable inventory.

Quick reference

Patient Screening and Documentation

  • Screen for contraindications before every dose: severe allergic reaction to a prior dose or vaccine component, and for live vaccines, pregnancy or significant immunocompromise.

  • Moderate or severe acute illness with or without fever is a precaution to defer vaccination; mild illness is not a reason to defer.

  • Document the vaccine name, manufacturer, lot number, expiration date, dose volume, route, site, date, and administering clinician.

  • Report the dose to the state or local immunization information system (IIS) within the timeframe required by jurisdiction.

  • A patient history of Guillain-Barre syndrome after influenza vaccine, or of thrombocytopenia after MMR, is a precaution requiring risk-benefit discussion.

  • Egg allergy is not a contraindication to any routinely recommended vaccine; severe allergy to a vaccine component is.

  • Record the patient's preferred language, consent, and any VIS edition date and date given, as required by federal law.

  • Syncope precautions: observe patients for 15 minutes after vaccination, seated or lying down, and document the observation period.

Quick reference

Regulations, Safety, and Emergency Response

  • The National Childhood Vaccine Injury Act requires providing the current Vaccine Information Statement (VIS) before each dose and recording the VIS edition date and date given.

  • VAERS accepts reports of any adverse event after vaccination, whether or not causality is established; serious events and errors are reportable.

  • Pharmacists administer vaccines under state authority; scope, age limits, and prescriptive authority vary by state and must be verified.

  • Anaphylaxis management: epinephrine 1 mg/mL given IM in the mid-outer thigh at 0.01 mg/kg, max 0.5 mg per dose, repeat every 5-15 minutes as needed.

  • Emergency equipment must be immediately available at every vaccination site: epinephrine, 1 mL syringes with 1 to 1.5 inch needles, and a means to call emergency services.

  • Needlestick injuries: wash the site with soap and water, report immediately, and follow post-exposure evaluation for bloodborne pathogens.

  • Sharps must be disposed of in puncture-resistant, closable containers immediately after use; never recap a needle using two hands.

  • Live vaccines are contraindicated during pregnancy and in severe immunocompromise; inactivated vaccines are generally preferred in these groups.

Quick reference

Immunization Administration

  • The deltoid is the preferred IM site for adults and children 3 years and older; the vastus lateralis is preferred for infants and toddlers.

  • Needle length for IM depends on weight and gender: 1 inch for adults under 60 kg, 1 to 1.5 inches for adults 60 kg or more.

  • Subcutaneous injections are given at a 45-degree angle into the upper-outer triceps, using a 23-25 gauge, 5/8 inch needle.

  • Intradermal injections use a 26-27 gauge, 3/8 inch needle at a 5-15 degree angle, producing a wheal.

  • Do not aspirate before injecting a vaccine; inject at the same angle used for insertion.

  • When two injectable vaccines are given at one visit, use separate syringes and separate anatomic sites at least 1 inch apart.

  • For infants, the anterolateral thigh is preferred; the deltoid may be used starting around age 3 years when muscle mass is adequate.

Quick reference

Vaccine Storage and Handling

  • Refrigerated vaccines: 2 to 8 degrees C (36 to 46 degrees F); frozen vaccines: -50 to -15 degrees C (-58 to +5 degrees F).

  • Place a calibrated digital data logger with a buffered probe among the vaccines, and record min/max temperatures at least twice daily.

  • Store vaccines in the middle of the unit, away from walls, floor, and vents; do not store in doors or drawers.

  • Never store food or specimens in a vaccine refrigerator; water bottles in the door help buffer temperature.

  • On a temperature excursion, label affected vaccine DO NOT USE, quarantine it, and contact the manufacturer or immunization program.

  • Rotate stock first-expiry, first-out; check expiration dates monthly and remove expired product from usable inventory.

  • Keep the refrigerator and freezer plugged into a dedicated outlet; do not use power strips or extension cords, and post a Do Not Unplug sign.

Quick reference

Patient Screening and Documentation

  • Screen for contraindications before each dose: severe allergic reaction to a prior dose or component; for live vaccines, pregnancy or significant immunocompromise.

  • Moderate or severe acute illness is a precaution to defer; mild illness is not a reason to defer vaccination.

  • Document vaccine name, manufacturer, lot number, expiration date, dose volume, route, site, date, and administering clinician.

  • Report each dose to the state or local immunization information system (IIS) within the jurisdiction's required timeframe.

  • Provide the current Vaccine Information Statement (VIS) before each dose and document its edition date and the date given.

  • Observe patients for 15 minutes after vaccination, seated or lying down, and document the observation period.

  • Egg allergy is not a contraindication to any routinely recommended vaccine; severe allergy to a vaccine component is.

Quick reference

Regulations, Safety, and Emergency Response

  • The National Childhood Vaccine Injury Act requires providing the current VIS before each dose and recording the VIS edition date and date given.

  • VAERS accepts reports of any adverse event after vaccination, whether or not causality is established; serious events and errors are reportable.

  • Pharmacists administer vaccines under state authority; scope, age limits, and prescriptive authority vary by state and must be verified.

  • Anaphylaxis management: epinephrine 1 mg/mL IM in the mid-outer thigh at 0.01 mg/kg, max 0.5 mg per dose, repeat every 5-15 minutes as needed.

  • Emergency equipment must be immediately available at every vaccination site: epinephrine, 1 mL syringes with 1 to 1.5 inch needles, and a way to call emergency services.

  • Needlestick injuries: wash the site with soap and water, report immediately, and follow post-exposure evaluation for bloodborne pathogens.

  • Sharps go in puncture-resistant, closable containers immediately after use; never recap a needle using two hands.

Quick reference

Immunization Administration

  • The deltoid is the preferred IM site for adults and children 3 years and older; the vastus lateralis is preferred for infants and toddlers.

  • Needle length for IM depends on weight and gender: 1 inch for adults under 60 kg, 1 to 1.5 inches for adults 60 kg or more.

  • Subcutaneous injections are given at a 45-degree angle into the upper-outer triceps, using a 23-25 gauge, 5/8 inch needle.

  • Intradermal injections use a 26-27 gauge, 3/8 inch needle at a 5-15 degree angle, producing a wheal.

  • Do not aspirate before injecting a vaccine; inject at the same angle used for insertion.

  • When two injectable vaccines are given at one visit, use separate syringes and separate anatomic sites at least 1 inch apart.

  • For infants, the anterolateral thigh is preferred; the deltoid may be used starting around age 3 years when muscle mass is adequate.

Quick reference

Vaccine Storage and Handling

  • Refrigerated vaccines: 2 to 8 degrees C (36 to 46 degrees F); frozen vaccines: -50 to -15 degrees C (-58 to +5 degrees F).

  • Place a calibrated digital data logger with a buffered probe among the vaccines, and record min/max temperatures at least twice daily.

  • Store vaccines in the middle of the unit, away from walls, floor, and vents; do not store in doors or drawers.

  • Never store food or specimens in a vaccine refrigerator; water bottles in the door help buffer temperature.

  • On a temperature excursion, label affected vaccine DO NOT USE, quarantine it, and contact the manufacturer or immunization program.

  • Rotate stock first-expiry, first-out; check expiration dates monthly and remove expired product from usable inventory.

  • Keep the refrigerator and freezer plugged into a dedicated outlet; do not use power strips or extension cords, and post a Do Not Unplug sign.

Quick reference

Patient Screening and Documentation

  • Screen for contraindications before each dose: severe allergic reaction to a prior dose or component; for live vaccines, pregnancy or significant immunocompromise.

  • Moderate or severe acute illness is a precaution to defer; mild illness is not a reason to defer vaccination.

  • Document vaccine name, manufacturer, lot number, expiration date, dose volume, route, site, date, and administering clinician.

  • Report each dose to the state or local immunization information system (IIS) within the jurisdiction's required timeframe.

  • Provide the current Vaccine Information Statement (VIS) before each dose and document its edition date and the date given.

  • Observe patients for 15 minutes after vaccination, seated or lying down, and document the observation period.

  • Egg allergy is not a contraindication to any routinely recommended vaccine; severe allergy to a vaccine component is.

Quick reference

Regulations, Safety, and Emergency Response

  • The National Childhood Vaccine Injury Act requires providing the current VIS before each dose and recording the VIS edition date and date given.

  • VAERS accepts reports of any adverse event after vaccination, whether or not causality is established; serious events and errors are reportable.

  • Pharmacists administer vaccines under state authority; scope, age limits, and prescriptive authority vary by state and must be verified.

  • Anaphylaxis management: epinephrine 1 mg/mL IM in the mid-outer thigh at 0.01 mg/kg, max 0.5 mg per dose, repeat every 5-15 minutes as needed.

  • Emergency equipment must be immediately available at every vaccination site: epinephrine, 1 mL syringes with 1 to 1.5 inch needles, and a way to call emergency services.

  • Needlestick injuries: wash the site with soap and water, report immediately, and follow post-exposure evaluation for bloodborne pathogens.

  • Sharps go in puncture-resistant, closable containers immediately after use; never recap a needle using two hands.

Quick reference

Immunization Administration

  • The deltoid is the preferred IM site for adults and children 3 years and older; the vastus lateralis is preferred for infants and toddlers.

  • Needle length for IM depends on weight and gender: 1 inch for adults under 60 kg, 1 to 1.5 inches for adults 60 kg or more.

  • Subcutaneous injections are given at a 45-degree angle into the upper-outer triceps, using a 23-25 gauge, 5/8 inch needle.

  • Intradermal injections use a 26-27 gauge, 3/8 inch needle at a 5-15 degree angle, producing a wheal.

  • Do not aspirate before injecting a vaccine; inject at the same angle used for insertion.

  • When two injectable vaccines are given at one visit, use separate syringes and separate anatomic sites at least 1 inch apart.

  • For infants, the anterolateral thigh is preferred; the deltoid may be used starting around age 3 years when muscle mass is adequate.

Quick reference

Vaccine Storage and Handling

  • Refrigerated vaccines: 2 to 8 degrees C (36 to 46 degrees F); frozen vaccines: -50 to -15 degrees C (-58 to +5 degrees F).

  • Place a calibrated digital data logger with a buffered probe among the vaccines, and record min/max temperatures at least twice daily.

  • Store vaccines in the middle of the unit, away from walls, floor, and vents; do not store in doors or drawers.

  • Never store food or specimens in a vaccine refrigerator; water bottles in the door help buffer temperature.

  • On a temperature excursion, label affected vaccine DO NOT USE, quarantine it, and contact the manufacturer or immunization program.

  • Rotate stock first-expiry, first-out; check expiration dates monthly and remove expired product from usable inventory.

  • Keep the refrigerator and freezer plugged into a dedicated outlet; do not use power strips or extension cords, and post a Do Not Unplug sign.

Quick reference

Patient Screening and Documentation

  • Screen for contraindications before each dose: severe allergic reaction to a prior dose or component; for live vaccines, pregnancy or significant immunocompromise.

  • Moderate or severe acute illness is a precaution to defer; mild illness is not a reason to defer vaccination.

  • Document vaccine name, manufacturer, lot number, expiration date, dose volume, route, site, date, and administering clinician.

  • Report each dose to the state or local immunization information system (IIS) within the jurisdiction's required timeframe.

  • Provide the current Vaccine Information Statement (VIS) before each dose and document its edition date and the date given.

  • Observe patients for 15 minutes after vaccination, seated or lying down, and document the observation period.

  • Egg allergy is not a contraindication to any routinely recommended vaccine; severe allergy to a vaccine component is.

Quick reference

Regulations, Safety, and Emergency Response

  • The National Childhood Vaccine Injury Act requires providing the current VIS before each dose and recording the VIS edition date and date given.

  • VAERS accepts reports of any adverse event after vaccination, whether or not causality is established; serious events and errors are reportable.

  • Pharmacists administer vaccines under state authority; scope, age limits, and prescriptive authority vary by state and must be verified.

  • Anaphylaxis management: epinephrine 1 mg/mL IM in the mid-outer thigh at 0.01 mg/kg, max 0.5 mg per dose, repeat every 5-15 minutes as needed.

  • Emergency equipment must be immediately available at every vaccination site: epinephrine, 1 mL syringes with 1 to 1.5 inch needles, and a way to call emergency services.

  • Needlestick injuries: wash the site with soap and water, report immediately, and follow post-exposure evaluation for bloodborne pathogens.

  • Sharps go in puncture-resistant, closable containers immediately after use; never recap a needle using two hands.

Quick reference

Immunization Administration

  • The deltoid is the preferred IM site for adults and children 3 years and older; the vastus lateralis is preferred for infants and toddlers.

  • Needle length for IM depends on weight and gender: 1 inch for adults under 60 kg, 1 to 1.5 inches for adults 60 kg or more.

  • Subcutaneous injections are given at a 45-degree angle into the upper-outer triceps, using a 23-25 gauge, 5/8 inch needle.

  • Intradermal injections use a 26-27 gauge, 3/8 inch needle at a 5-15 degree angle, producing a wheal.

  • Do not aspirate before injecting a vaccine; inject at the same angle used for insertion.

  • When two injectable vaccines are given at one visit, use separate syringes and separate anatomic sites at least 1 inch apart.

  • For infants, the anterolateral thigh is preferred; the deltoid may be used starting around age 3 years when muscle mass is adequate.

Quick reference

Vaccine Storage and Handling

  • Refrigerated vaccines: 2 to 8 degrees C (36 to 46 degrees F); frozen vaccines: -50 to -15 degrees C (-58 to +5 degrees F).

  • Place a calibrated digital data logger with a buffered probe among the vaccines, and record min/max temperatures at least twice daily.

  • Store vaccines in the middle of the unit, away from walls, floor, and vents; do not store in doors or drawers.

  • Never store food or specimens in a vaccine refrigerator; water bottles in the door help buffer temperature.

  • On a temperature excursion, label affected vaccine DO NOT USE, quarantine it, and contact the manufacturer or immunization program.

  • Rotate stock first-expiry, first-out; check expiration dates monthly and remove expired product from usable inventory.

  • Keep the refrigerator and freezer plugged into a dedicated outlet; do not use power strips or extension cords, and post a Do Not Unplug sign.

Quick reference

Patient Screening and Documentation

  • Screen for contraindications before each dose: severe allergic reaction to a prior dose or component; for live vaccines, pregnancy or significant immunocompromise.

  • Moderate or severe acute illness is a precaution to defer; mild illness is not a reason to defer vaccination.

  • Document vaccine name, manufacturer, lot number, expiration date, dose volume, route, site, date, and administering clinician.

  • Report each dose to the state or local immunization information system (IIS) within the jurisdiction's required timeframe.

  • Provide the current Vaccine Information Statement (VIS) before each dose and document its edition date and the date given.

  • Observe patients for 15 minutes after vaccination, seated or lying down, and document the observation period.

  • Egg allergy is not a contraindication to any routinely recommended vaccine; severe allergy to a vaccine component is.

Quick reference

Regulations, Safety, and Emergency Response

  • The National Childhood Vaccine Injury Act requires providing the current VIS before each dose and recording the VIS edition date and date given.

  • VAERS accepts reports of any adverse event after vaccination, whether or not causality is established; serious events and errors are reportable.

  • Pharmacists administer vaccines under state authority; scope, age limits, and prescriptive authority vary by state and must be verified.

  • Anaphylaxis management: epinephrine 1 mg/mL IM in the mid-outer thigh at 0.01 mg/kg, max 0.5 mg per dose, repeat every 5-15 minutes as needed.

  • Emergency equipment must be immediately available at every vaccination site: epinephrine, 1 mL syringes with 1 to 1.5 inch needles, and a way to call emergency services.

  • Needlestick injuries: wash the site with soap and water, report immediately, and follow post-exposure evaluation for bloodborne pathogens.

  • Sharps go in puncture-resistant, closable containers immediately after use; never recap a needle using two hands.

Quick reference

Immunization Administration

  • The deltoid is the preferred IM site for adults and children 3 years and older; the vastus lateralis is preferred for infants and toddlers.

  • Needle length for IM depends on weight and gender: 1 inch for adults under 60 kg, 1 to 1.5 inches for adults 60 kg or more.

  • Subcutaneous injections are given at a 45-degree angle into the upper-outer triceps, using a 23-25 gauge, 5/8 inch needle.

  • Intradermal injections use a 26-27 gauge, 3/8 inch needle at a 5-15 degree angle, producing a wheal.

  • Do not aspirate before injecting a vaccine; inject at the same angle used for insertion.

  • When two injectable vaccines are given at one visit, use separate syringes and separate anatomic sites at least 1 inch apart.

  • For infants, the anterolateral thigh is preferred; the deltoid may be used starting around age 3 years when muscle mass is adequate.

Quick reference

Vaccine Storage and Handling

  • Refrigerated vaccines: 2 to 8 degrees C (36 to 46 degrees F); frozen vaccines: -50 to -15 degrees C (-58 to +5 degrees F).

  • Place a calibrated digital data logger with a buffered probe among the vaccines, and record min/max temperatures at least twice daily.

  • Store vaccines in the middle of the unit, away from walls, floor, and vents; do not store in doors or drawers.

  • Never store food or specimens in a vaccine refrigerator; water bottles in the door help buffer temperature.

  • On a temperature excursion, label affected vaccine DO NOT USE, quarantine it, and contact the manufacturer or immunization program.

  • Rotate stock first-expiry, first-out; check expiration dates monthly and remove expired product from usable inventory.

  • Keep the refrigerator and freezer plugged into a dedicated outlet; do not use power strips or extension cords, and post a Do Not Unplug sign.

Quick reference

Patient Screening and Documentation

  • Screen for contraindications before each dose: severe allergic reaction to a prior dose or component; for live vaccines, pregnancy or significant immunocompromise.

  • Moderate or severe acute illness is a precaution to defer; mild illness is not a reason to defer vaccination.

  • Document vaccine name, manufacturer, lot number, expiration date, dose volume, route, site, date, and administering clinician.

  • Report each dose to the state or local immunization information system (IIS) within the jurisdiction's required timeframe.

  • Provide the current Vaccine Information Statement (VIS) before each dose and document its edition date and the date given.

  • Observe patients for 15 minutes after vaccination, seated or lying down, and document the observation period.

  • Egg allergy is not a contraindication to any routinely recommended vaccine; severe allergy to a vaccine component is.

Quick reference

Regulations, Safety, and Emergency Response

  • The National Childhood Vaccine Injury Act requires providing the current VIS before each dose and recording the VIS edition date and date given.

  • VAERS accepts reports of any adverse event after vaccination, whether or not causality is established; serious events and errors are reportable.

  • Pharmacists administer vaccines under state authority; scope, age limits, and prescriptive authority vary by state and must be verified.

  • Anaphylaxis management: epinephrine 1 mg/mL IM in the mid-outer thigh at 0.01 mg/kg, max 0.5 mg per dose, repeat every 5-15 minutes as needed.

  • Emergency equipment must be immediately available at every vaccination site: epinephrine, 1 mL syringes with 1 to 1.5 inch needles, and a way to call emergency services.

  • Needlestick injuries: wash the site with soap and water, report immediately, and follow post-exposure evaluation for bloodborne pathogens.

  • Sharps go in puncture-resistant, closable containers immediately after use; never recap a needle using two hands.

Quick reference

Immunization Administration

  • The deltoid is the preferred IM site for adults and children 3 years and older; the vastus lateralis is preferred for infants and toddlers.

  • Needle length for IM depends on weight and gender: 1 inch for adults under 60 kg, 1 to 1.5 inches for adults 60 kg or more.

  • Subcutaneous injections are given at a 45-degree angle into the upper-outer triceps, using a 23-25 gauge, 5/8 inch needle.

  • Intradermal injections use a 26-27 gauge, 3/8 inch needle at a 5-15 degree angle, producing a wheal.

  • Do not aspirate before injecting a vaccine; inject at the same angle used for insertion.

  • When two injectable vaccines are given at one visit, use separate syringes and separate anatomic sites at least 1 inch apart.

  • For infants, the anterolateral thigh is preferred; the deltoid may be used starting around age 3 years when muscle mass is adequate.

Quick reference

Vaccine Storage and Handling

  • Refrigerated vaccines: 2 to 8 degrees C (36 to 46 degrees F); frozen vaccines: -50 to -15 degrees C (-58 to +5 degrees F).

  • Place a calibrated digital data logger with a buffered probe among the vaccines, and record min/max temperatures at least twice daily.

  • Store vaccines in the middle of the unit, away from walls, floor, and vents; do not store in doors or drawers.

  • Never store food or specimens in a vaccine refrigerator; water bottles in the door help buffer temperature.

  • On a temperature excursion, label affected vaccine DO NOT USE, quarantine it, and contact the manufacturer or immunization program.

  • Rotate stock first-expiry, first-out; check expiration dates monthly and remove expired product from usable inventory.

  • Keep the refrigerator and freezer plugged into a dedicated outlet; do not use power strips or extension cords, and post a Do Not Unplug sign.

Quick reference

Patient Screening and Documentation

  • Screen for contraindications before each dose: severe allergic reaction to a prior dose or component; for live vaccines, pregnancy or significant immunocompromise.

  • Moderate or severe acute illness is a precaution to defer; mild illness is not a reason to defer vaccination.

  • Document vaccine name, manufacturer, lot number, expiration date, dose volume, route, site, date, and administering clinician.

  • Report each dose to the state or local immunization information system (IIS) within the jurisdiction's required timeframe.

  • Provide the current Vaccine Information Statement (VIS) before each dose and document its edition date and the date given.

  • Observe patients for 15 minutes after vaccination, seated or lying down, and document the observation period.

  • Egg allergy is not a contraindication to any routinely recommended vaccine; severe allergy to a vaccine component is.

Quick reference

Regulations, Safety, and Emergency Response

  • The National Childhood Vaccine Injury Act requires providing the current VIS before each dose and recording the VIS edition date and date given.

  • VAERS accepts reports of any adverse event after vaccination, whether or not causality is established; serious events and errors are reportable.

  • Pharmacists administer vaccines under state authority; scope, age limits, and prescriptive authority vary by state and must be verified.

  • Anaphylaxis management: epinephrine 1 mg/mL IM in the mid-outer thigh at 0.01 mg/kg, max 0.5 mg per dose, repeat every 5-15 minutes as needed.

  • Emergency equipment must be immediately available at every vaccination site: epinephrine, 1 mL syringes with 1 to 1.5 inch needles, and a way to call emergency services.

  • Needlestick injuries: wash the site with soap and water, report immediately, and follow post-exposure evaluation for bloodborne pathogens.

  • Sharps go in puncture-resistant, closable containers immediately after use; never recap a needle using two hands.

Quick reference

Immunization Administration

  • The deltoid is the preferred IM site for adults and children 3 years and older; the vastus lateralis is preferred for infants and toddlers.

  • Needle length for IM depends on weight and gender: 1 inch for adults under 60 kg, 1 to 1.5 inches for adults 60 kg or more.

  • Subcutaneous injections are given at a 45-degree angle into the upper-outer triceps, using a 23-25 gauge, 5/8 inch needle.

  • Intradermal injections use a 26-27 gauge, 3/8 inch needle at a 5-15 degree angle, producing a wheal.

  • Do not aspirate before injecting a vaccine; inject at the same angle used for insertion.

  • When two injectable vaccines are given at one visit, use separate syringes and separate anatomic sites at least 1 inch apart.

  • For infants, the anterolateral thigh is preferred; the deltoid may be used starting around age 3 years when muscle mass is adequate.

Quick reference

Vaccine Storage and Handling

  • Refrigerated vaccines: 2 to 8 degrees C (36 to 46 degrees F); frozen vaccines: -50 to -15 degrees C (-58 to +5 degrees F).

  • Place a calibrated digital data logger with a buffered probe among the vaccines, and record min/max temperatures at least twice daily.

  • Store vaccines in the middle of the unit, away from walls, floor, and vents; do not store in doors or drawers.

  • Never store food or specimens in a vaccine refrigerator; water bottles in the door help buffer temperature.

  • On a temperature excursion, label affected vaccine DO NOT USE, quarantine it, and contact the manufacturer or immunization program.

  • Rotate stock first-expiry, first-out; check expiration dates monthly and remove expired product from usable inventory.

  • Keep the refrigerator and freezer plugged into a dedicated outlet; do not use power strips or extension cords, and post a Do Not Unplug sign.

Quick reference

Patient Screening and Documentation

  • Screen for contraindications before each dose: severe allergic reaction to a prior dose or component; for live vaccines, pregnancy or significant immunocompromise.

  • Moderate or severe acute illness is a precaution to defer; mild illness is not a reason to defer vaccination.

  • Document vaccine name, manufacturer, lot number, expiration date, dose volume, route, site, date, and administering clinician.

  • Report each dose to the state or local immunization information system (IIS) within the jurisdiction's required timeframe.

  • Provide the current Vaccine Information Statement (VIS) before each dose and document its edition date and the date given.

  • Observe patients for 15 minutes after vaccination, seated or lying down, and document the observation period.

  • Egg allergy is not a contraindication to any routinely recommended vaccine; severe allergy to a vaccine component is.

Quick reference

Regulations, Safety, and Emergency Response

  • The National Childhood Vaccine Injury Act requires providing the current VIS before each dose and recording the VIS edition date and date given.

  • VAERS accepts reports of any adverse event after vaccination, whether or not causality is established; serious events and errors are reportable.

  • Pharmacists administer vaccines under state authority; scope, age limits, and prescriptive authority vary by state and must be verified.

  • Anaphylaxis management: epinephrine 1 mg/mL IM in the mid-outer thigh at 0.01 mg/kg, max 0.5 mg per dose, repeat every 5-15 minutes as needed.

  • Emergency equipment must be immediately available at every vaccination site: epinephrine, 1 mL syringes with 1 to 1.5 inch needles, and a way to call emergency services.

  • Needlestick injuries: wash the site with soap and water, report immediately, and follow post-exposure evaluation for bloodborne pathogens.

  • Sharps go in puncture-resistant, closable containers immediately after use; never recap a needle using two hands.