FVH Pathologie key terms

A structured description of a lesion by features such as organ, distribution, severity, duration and type of pathological process.

Postmortem tissue degradation that can obscure diagnostic architecture or complicate distinction between actual disease and later change.

A tissue technique identifying selected antigens using antibodies, interpreted with controls, morphology and the actual test limitations.

A postmortem discoloration involving sulfur compounds and tissue iron, distinguished from pigmentation produced by disease during life.

Postmortem muscle stiffening related to energy depletion and cross-bridge behavior, whose course depends on tissue and environmental conditions.

Material selected to reflect the actual lesion and diagnostic question, with suitable identification and handling for the intended laboratory investigation.

A pattern of cell death in which tissue outlines can initially remain recognizable despite loss of viable cells.

An inflammatory injury pattern involving the epidermal basal region and its interface, interpreted with other features and clinical evidence.

An extracellular protein deposit recognized through appropriate morphology and special staining, with further typing needed for its particular composition.

A population pattern supporting common cellular origin, which requires context because it is not automatically synonymous with malignant disease.

The pattern of selected antigen expression in a cell population, assessed using appropriate validated markers and controls.

Detection of a selected nucleic-acid target within preserved tissue location, linking its signal to relevant cells and architecture.

Evidence that the relevant erythropoietic system is responding to anemia, interpreted according to species, timing and the selected measurements.

An increased representation of immature neutrophil forms in circulation, interpreted with mature-cell numbers, toxic change and clinical context.

A comparison of a cavity-fluid measurement with a contemporaneous relevant blood measurement to support a particular pathophysiological interpretation.

A microscopic assessment within a defined tumor-specific system, distinct from anatomical stage and not a guarantee of individual outcome.

Bone matrix produced directly by neoplastic cells, which can support an osteosarcoma diagnosis in an appropriate pathological context.

A resection surface examined in submitted tissue sections, whose findings depend on orientation, preparation and the sampling performed.

Marked cellular and nuclear enlargement that can occur in relevant hepatotoxic patterns, interpreted with exposure and other pathological evidence.

A skeletal change involving increased resorption and fibrous tissue replacement under the relevant endocrine and mineral circumstances.

Identification or measurement of a target substance under specified test conditions, distinguished from proof that it caused the observed lesions.