Facharzt FMH Dermatologie und Venerologie - independent subject foundations key terms

Intercellular epidermal edema that supports an eczematous reaction pattern but must be interpreted with the actual clinical and histological differential.

Loss of cohesion among keratinocytes that can contribute to intraepidermal separation in several acquired or inherited skin disorders.

A reaction pattern involving injury near the dermoepidermal junction, interpreted with infiltrate, accompanying changes and the clinical context.

A cell-to-cell adhesion structure whose components help connect neighboring keratinocytes and can be targets in blistering disease.

A basal-cell adhesion structure linking intracellular filaments with the basement-membrane region rather than joining two neighboring keratinocytes.

A structural component involving type VII collagen that helps attach the basement-membrane region to underlying dermal connective tissue.

Examination of appropriately selected tissue for deposited immunoreactants, with interpretation influenced by site, handling and the clinical setting.

A method separating skin at an artificial plane to help localize immunoreactivity, interpreted alongside antigen testing and clinical features.

The measured vertical thickness of an invasive melanoma using the applicable pathological convention, contributing to staging and management decisions.

Loss of the overlying epidermal covering in a relevant pathological context, an important staging feature when assessed in melanoma.

A surgical approach using mapped histological margin assessment in appropriate tumors, intended to combine clearance assessment with tissue conservation.

Tumor involvement of a nerve-related compartment that can influence risk assessment and management under the actual tumor framework.

An antibody-excess effect that can interfere with certain serological reactions and cause misleadingly negative results in an undiluted specimen.

A dermatophyte infection with morphology altered by inappropriate anti-inflammatory treatment, making clinical recognition and sampling more challenging.

An exaggerated lesion response after relatively minor trauma in certain inflammatory conditions, relevant to assessment and procedural planning.

An inherited condition with cutaneous manifestations that may also require evaluation of extracutaneous findings and the relevant inheritance pattern.

A vascular tumor with a characteristic postnatal growth and subsequent evolution, distinct from the behavior of a capillary malformation.

An immune response to an external substance that must be assessed for actual clinical relevance rather than equated with every positive test.

A cutaneous reaction associated with a medicine exposure, classified using timing, morphology, systemic features and competing explanations.

Integration of clinical history, morphology, tissue findings and laboratory evidence so that one isolated result is not treated as a complete diagnosis.