Egyptian Board Hematology - independent subject foundations key terms
Egyptian Board Hematology - independent subject foundations · Get comfortable with the vocabulary.
- Reticulocyte response
A measure of young red-cell production interpreted relative to the anemia and treatment context rather than as an isolated percentage.
- Hepcidin
A systemic iron-regulatory hormone influencing ferroportin-mediated iron export and linking absorption, storage and inflammatory signals.
- Ferroportin
An iron-export protein whose expression and hepcidin response affect the distribution and availability of iron.
- Ineffective erythropoiesis
Failure of adequate mature red-cell output despite erythroid activity, relevant to several nutritional, globin and marrow disorders.
- Direct antiglobulin test
A test for immunoglobulin or complement coating of red cells, interpreted separately from serum antibody screening.
- Alloantibody
An antibody directed at an antigen from another individual of the same species, potentially relevant to transfusion compatibility.
- Anamnestic response
Renewed immune production after re-exposure to a previously recognized antigen, potentially explaining a delayed transfusion reaction.
- Leukoreduction
Reduction of donor leukocytes in a blood component, which addresses selected risks but does not replace every other modification.
- Component irradiation
Treatment of relevant cellular blood components to prevent viable donor lymphocytes from causing transfusion-associated graft-versus-host disease.
- Corrected count increment
A platelet-response measure that accounts for the actual count change, body size and transfused platelet dose.
- ADAMTS13
A protease involved in processing von Willebrand factor, whose severe deficiency is central to important TTP presentations.
- Lupus anticoagulant
An assay-related antiphospholipid phenomenon that can prolong certain clotting tests despite association with thrombotic rather than simple bleeding risk.
- Mixing study
A coagulation-assay investigation using patient and normal plasma to help assess deficiency, inhibition and relevant interference.
- Factor inhibitor
An antibody or other inhibiting influence affecting the measured or clinical activity of a particular coagulation factor.
- Nonheparin anticoagulant
An anticoagulant from another class considered in relevant settings such as HIT, with selection dependent on the individual context.
- Chimerism
The measured contribution of donor and recipient cells after transplantation, interpreted with timing, method and the actual disease course.
- Graft-versus-leukemia effect
Donor immune activity contributing to control of a hematologic malignancy after an appropriate allogeneic transplantation.
- Minimal residual disease
A context-dependent assessment of persisting disease below conventional detection, using a specified validated method and time point.
- Differentiation syndrome
A potentially serious inflammatory complication of certain differentiation therapies requiring recognition through the actual clinical pattern.
- Clonal hematopoiesis
Blood-cell production from an acquired clone, which is not by itself equivalent to every overt hematologic malignancy.