ENP-BC study materials
ENP-BC study resources

ENP-BC key terms

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Differential diagnosis

The ranked list of possible conditions that could explain a patient's presenting signs and symptoms, narrowed through history, examination, and targeted testing before a working diagnosis is confirmed.

Related: Clinical reasoning, Diagnostic stewardship
Clinical reasoning

The cognitive process of gathering cues, generating hypotheses, weighing evidence, and revising conclusions to reach safe decisions, including recognizing when initial assumptions may be wrong.

Related: Differential diagnosis, Diagnostic stewardship
Diagnostic stewardship

Ordering the right test for the right patient at the right time, avoiding low-value testing that invites false positives, incidental findings, and unnecessary follow-up or treatment.

Related: Differential diagnosis, Sensitivity and specificity
Sensitivity and specificity

Sensitivity is the proportion of truly affected patients a test correctly identifies; specificity is the proportion of unaffected patients it correctly clears. Both are properties of the test, not the patient.

Related: Positive predictive value, Diagnostic stewardship
Positive predictive value

The probability that a patient with a positive result actually has the condition. It rises with disease prevalence, so the same test performs differently across settings and risk groups.

Related: Sensitivity and specificity, Pre-test probability
Pre-test probability

The estimated likelihood a condition is present before a test is ordered, derived from prevalence, history, and risk factors. It determines how much a result should shift clinical decisions.

Related: Positive predictive value, Differential diagnosis
SBAR handoff

A structured communication format covering Situation, Background, Assessment, and Recommendation, used to transfer patient information concisely and reduce omissions during transitions of care.

Related: Closed-loop communication, Time-out
Closed-loop communication

A technique in which the sender gives a directive, the receiver repeats it back, and the sender confirms accuracy, preventing misheard orders during high-stakes or noisy clinical moments.

Related: SBAR handoff, Speak-up culture
Time-out

A brief pre-procedure pause by the whole team to verbally confirm patient identity, procedure, site, consent, and relevant risks before starting, regardless of setting or urgency.

Related: SBAR handoff, Informed consent
Speak-up culture

An environment where any team member, regardless of rank, can raise safety concerns without fear of retaliation, supported by leadership behavior and clear escalation pathways.

Related: Closed-loop communication, Just culture
Just culture

A framework that distinguishes human error, at-risk behavior, and reckless conduct, responding with support, coaching, or sanction respectively rather than blaming individuals for system failures.

Related: Root cause analysis, Speak-up culture
Root cause analysis

A structured retrospective review of a serious event that maps contributing factors across people, equipment, environment, and process, then produces actionable system-level recommendations.

Related: Just culture, Plan-do-study-act cycle
Plan-do-study-act cycle

A small-scale iterative improvement method: plan a change, test it, study the results, and act on what was learned, repeated to refine processes before wider spread.

Related: Root cause analysis, Clinical audit
Clinical audit

A quality improvement method that compares current practice against an agreed standard, identifies gaps, implements changes, and re-measures to confirm improvement.

Related: Plan-do-study-act cycle, Benchmarking
Benchmarking

Comparing one's own performance metrics against internal targets or peer organizations to identify variation and prioritize improvement work.

Related: Clinical audit, Key performance indicator
Key performance indicator

A quantifiable measure chosen to track progress toward a specific operational or clinical goal, such as door-to-treatment time or hand hygiene compliance.

Related: Benchmarking, Clinical audit
Informed consent

A patient's voluntary agreement to a proposed intervention after receiving and understanding information about its nature, benefits, risks, and alternatives, including the option to decline.

Related: Decision-making capacity, Time-out
Decision-making capacity

A patient's ability to understand relevant information, appreciate the consequences, reason through options, and communicate a consistent choice about a specific decision at a specific time.

Related: Informed consent, Advance directive
Advance directive

A written statement made while a patient has capacity that records preferences for future care, or names a substitute decision-maker, to guide treatment when the patient cannot speak.

Related: Decision-making capacity, Duty to warn
Duty to warn

The legal and ethical obligation to breach confidentiality when a patient poses a credible, serious threat of harm to an identifiable person, disclosing only what is necessary to protect them.

Related: Advance directive, Mandatory reporting
Mandatory reporting

A legal requirement to notify designated authorities about specified events, such as suspected abuse, certain communicable diseases, or serious safety incidents, regardless of patient objection.

Related: Duty to warn, Just culture
Scope of practice

The activities, responsibilities, and limits a clinician is legally and professionally authorized to perform, defined by licensure, regulation, employer policy, and demonstrated competence.

Related: Delegation, Credentialing
Delegation

Assigning a task to another team member while retaining accountability for the outcome, requiring assessment of the delegate's competence, the task's risk, and appropriate supervision.

Related: Scope of practice, Closed-loop communication
Credentialing

The formal process of verifying a clinician's education, licensure, training, and experience to authorize practice privileges within an organization.

Related: Scope of practice, Clinical audit
Pharmacokinetics

What the body does to a drug: absorption, distribution, metabolism, and elimination. These determine the onset, intensity, and duration of effect at a given dose.

Related: Pharmacodynamics, Therapeutic index
Pharmacodynamics

What a drug does to the body, including receptor binding, dose-response relationships, and the mechanisms that produce both intended effects and adverse effects.

Related: Pharmacokinetics, Therapeutic index
Therapeutic index

The ratio between a drug's toxic dose and its effective dose. A narrow index means small dose changes or interactions can cause toxicity, so monitoring is required.

Related: Pharmacokinetics, Steady state
Steady state

The point at which drug intake equals elimination, producing relatively stable plasma concentrations. It is typically reached after about four to five half-lives of regular dosing.

Related: Half-life, Loading dose
Half-life

The time required for plasma concentration to fall by half. It guides dosing intervals, predicts time to steady state, and informs how long effects persist after stopping a drug.

Related: Steady state, Loading dose
Loading dose

A larger initial dose given to reach therapeutic concentration quickly when waiting several half-lives for accumulation would delay treatment, as in some antimicrobials or antiarrhythmics.

Related: Steady state, Half-life
Off-label prescribing

Prescribing an approved medicine for an indication, dose, route, or population not covered by its marketing authorization, which should be supported by evidence and explained to the patient.

Related: Informed consent, Adverse drug event
Adverse drug event

Any harm associated with a medication, whether from an expected side effect, an allergic reaction, a dosing error, or an interaction, including harm from omission of needed therapy.

Related: High-alert medication, Polypharmacy
High-alert medication

A drug class carrying elevated risk of serious harm when used incorrectly, such as anticoagulants, insulin, opioids, and concentrated electrolytes, requiring independent double-checks and standardized protocols.

Related: Adverse drug event, Independent double-check
Independent double-check

Two clinicians separately verify a calculation, dose, or product without seeing each other's work, then compare results, reducing the chance that a shared error goes unnoticed.

Related: High-alert medication, Time-out
Polypharmacy

Use of multiple medications concurrently, often five or more, which raises interaction and adverse effect risk and warrants periodic review for continued indication.

Related: Adverse drug event, Deprescribing
Deprescribing

The planned, supervised withdrawal or dose reduction of medicines that no longer provide benefit, are causing harm, or conflict with the patient's goals of care.

Related: Polypharmacy, Advance directive
Triage

Rapid sorting of patients by acuity and resource need to prioritize care when demand exceeds capacity, using a validated scale and reassessment as conditions change.

Related: Early warning score, Escalation of care
Early warning score

A composite score calculated from routine vital signs that flags physiological deterioration and triggers a defined clinical response before obvious collapse occurs.

Related: Triage, Escalation of care
Escalation of care

Activating more senior or specialized help when a patient's condition worsens or fails to improve, following a pre-agreed threshold and pathway rather than waiting for review.

Related: Early warning score, SBAR handoff
Rapid sequence intubation

Sequential administration of a sedative and a neuromuscular blocker to secure the airway quickly while minimizing aspiration risk, with pre-oxygenation, planning, and rescue equipment ready.

Related: Airway assessment, Capnography
Capnography

Continuous measurement and display of exhaled carbon dioxide, used to confirm and monitor endotracheal tube placement and to detect dislodgement, apnea, or low cardiac output.

Related: Rapid sequence intubation, Airway assessment
Airway assessment

Structured evaluation of predictors of difficult ventilation or intubation, such as mouth opening, neck mobility, and anatomy, performed before airway manipulation to plan backup strategies.

Related: Rapid sequence intubation, Capnography
Aseptic technique

A set of practices that prevent contamination of a sterile field or invasive site, including hand hygiene, sterile barriers, and maintaining separation of sterile from non-sterile items.

Related: Surgical safety checklist, Central line-associated bloodstream infection
Surgical safety checklist

A standardized verbal checklist used at sign-in, time-out, and sign-out to confirm identity, procedure, equipment, and counts, reducing omissions and wrong-site events.

Related: Time-out, Aseptic technique
Central line-associated bloodstream infection

A bloodstream infection attributed to a central venous catheter in the absence of another source, prevented through insertion bundles, site care, and prompt removal when no longer needed.

Related: Aseptic technique, Bundle of care
Bundle of care

A small set of evidence-based interventions implemented together for a defined situation, where compliance with all elements is measured rather than each in isolation.

Related: Central line-associated bloodstream infection, Clinical audit
Teach-back method

Asking the patient to restate information in their own words to confirm understanding, allowing the clinician to correct gaps rather than assuming that explaining equals learning.

Related: Health literacy, Motivational interviewing
Health literacy

A person's ability to obtain, understand, and act on health information. Low literacy is common and is best addressed with plain language, chunking, and visual aids.

Related: Teach-back method, Shared decision-making
Motivational interviewing

A collaborative conversation style that elicits a patient's own reasons for change through open questions, reflective listening, and affirmation, rather than advice-giving or confrontation.

Related: Teach-back method, Shared decision-making
Shared decision-making

A partnership in which clinician and patient exchange evidence and preferences to reach an agreed plan, especially where options carry trade-offs in benefit and burden.

Related: Health literacy, Informed consent