EBOT case studies
EBOT · Put your knowledge to work in context.
The EBOT (European Board of Oncology Training) examination is a European-level knowledge assessment in medical oncology, typically taken by trainees near the end of specialist training and by practising oncologists who want an external benchmark of their knowledge. It tests the breadth of oncology practice rather than a single school of thought: diagnostic work-up and staging, the choice and sequencing of systemic therapy including targeted agents and immunotherapy, radiation and surgical principles within multidisciplinary care, supportive and palliative care, oncologic emergencies, the interpretation of clinical evidence and statistics, and the professional, ethical and communication skills that shape daily decisions. The EBOT case studies are 5 cases and about 4,150 words.
1Neutropenic sepsis on day 9 of adjuvant TC chemotherapy
A 62-year-old woman with a pT2 pN1 (1/14 nodes), ER-positive, HER2-negative breast cancer started adjuvant docetaxel 75 mg/m² plus cyclophosphamide 600 mg/m² (TC) three weeks after surgery. She has no significant comorbidity, no central venous access device, and takes no regular medication apart from occasional paracetamol.
840 words, about 4 min2Grade 3 immune-mediated hepatitis on pembrolizumab in MSI-high colorectal cancer
A 44-year-old woman with Lynch syndrome and metastatic colorectal cancer (MSI-high, RAS/BRAF wild-type) began second-line pembrolizumab after progression on FOLFOX plus bevacizumab. At the 12-week scan she had a partial response, with her largest liver metastasis shrinking from 42 mm to 19 mm, and CEA falling from 210 to 34 µg/L.
835 words, about 4 min3Threatened circumferential margin in mid-rectal cancer: choosing neoadjuvant treatment
A 60-year-old man is diagnosed with adenocarcinoma of the mid-rectum, 7 cm from the anal verge, after presenting with rectal bleeding and a change in bowel habit. Pelvic MRI shows cT3c disease with 4 mm extramural extension, extramural venous invasion, and a threatened circumferential resection margin of 1 mm at the 4 o'clock position; three mesorectal nodes are suspicious.
843 words, about 4 min4Opioid toxicity in advanced prostate cancer with renal impairment
A 66-year-old man with metastatic castration-resistant prostate cancer and widespread bone metastases has been taking morphine sulfate modified-release 60 mg twice daily plus oxycodone immediate-release 10 mg as needed (4–5 doses per day) for the last 3 months. He now reports pain 8/10 despite this, and over the past week has become drowsy with myoclonic jerks, intermittent confusion and reduced oral intake.
817 words, about 4 min5Family-requested non-disclosure and a request for unproven therapy
A 71-year-old man with metastatic pancreatic adenocarcinoma has progressed after four cycles of FOLFIRINOX. His ECOG performance status is 1, and he lives with his wife and daughter.
815 words, about 4 min