EBOT study plan

Map every drug class in Domain 2 (cytotoxic, targeted small molecules and antibodies, checkpoint inhibitors, CAR-T, endocrine) onto a one-page mechanism-to-toxicity grid

Explain the mechanism of action, key indication, and dose-limiting toxicity for at least 15 high-yield agents from memory

Distinguish infusion-related reactions, cytokine release syndrome, and immune-related adverse events by timing, mechanism, and first-line management

Solve 25 Domain 2 practice items and log every error with the underlying knowledge gap and the correct reasoning

Compare first-line and salvage regimens for the five most common solid tumors and state the evidence basis for each

Justify treatment selection using biomarker results (e.g., HER2, EGFR, PD-L1, MSI status) in at least 10 clinical vignettes

Describe monitoring schedules and dose-modification rules for common toxicities such as neutropenia, neuropathy, and hepatotoxicity

Write a 10-line summary of immunotherapy toxicity grading and steroid-taper principles without consulting notes

Build a staging quick-reference for the six most tested tumor types using current TNM principles

Interpret pathology and molecular reports (grade, margins, receptors, mutations) and translate each into prognostic and treatment implications

Differentiate paraneoplastic syndromes and cancer-related metabolic abnormalities by tumor type and presenting labs

Complete 30 Domain 1 items under timed conditions and review every rationale

Explain the radiobiology behind fractionation, dose constraints, and normal-tissue tolerance in plain language

Compare external-beam, brachytherapy, and systemic radionuclide approaches by indication, intent, and toxicity profile

Recognize and grade acute versus late radiation toxicities and outline initial management for each

Integrate radiation sequencing questions (neoadjuvant, adjuvant, concurrent, palliative) into 15 case-based items

Outline the surgical principles of margin status, lymph node sampling, and neoadjuvant sequencing across four major cancer types

Explain the multidisciplinary tumor board workflow and the role of each discipline in a treatment decision

Construct a decision algorithm for febrile neutropenia including risk stratification, cultures, and empiric antibiotic timing

Differentiate oncologic emergencies (cord compression, tumor lysis, SVC obstruction, hypercalcemia, extravasation) by first 60-minute actions

Drill 20 emergency vignettes and commit the time-critical first step for each to memory

Select and titrate analgesics using the WHO ladder, equianalgesic conversion, and opioid rotation principles

Manage the top five non-pain symptoms (nausea, mucositis, constipation, dyspnea, fatigue) with evidence-based first-line options

Apply goals-of-care and palliative-care frameworks to at least five advanced-disease scenarios

Re-test the week 5 emergency card and correct any lapses in recall

Interpret p-values, confidence intervals, hazard ratios, and number needed to treat in the context of published oncology trials

Distinguish phase I to IV designs, non-inferiority, intention-to-treat, and common bias and confounding pitfalls

Critique a short abstract for internal and external validity and state whether the conclusion is supported

Complete 25 statistics and evidence-based-practice items and explain each distractor

Apply informed-consent, capacity, confidentiality, and error-disclosure principles to at least eight ethics scenarios

Demonstrate structured communication (breaking bad news, shared decision-making) in written scripts for three scenarios

Synthesize all domains with two full-length timed practice exams and a domain-by-domain accuracy breakdown

Build a final two-week review list of your ten weakest concepts ranked by error frequency