MTLE Life Science (Grades 9-12) study materials
MTLE Life Science (Grades 9-12) study resources

MTLE Life Science (Grades 9-12) study plan

MTLE Life Science (Grades 9-12) · Give each week a clear focus.

8 weeks · About 6 hours per week

Week 1

Cellular and Molecular Biology

  • Build a concept map linking the four macromolecule classes to their monomers, bonds, and cellular functions, reciting each from memory by week's end.

  • Diagram the endomembrane system and label the path a secreted protein takes from ribosome to extracellular space.

  • Compare prokaryotic and eukaryotic cell structures in a side-by-side table covering at least eight features.

  • Explain how the hydrophobic core of the plasma membrane constrains the movement of ions and polar molecules, using the terms diffusion, osmosis, and facilitated transport.

Your checkpoint

A hand-drawn or digital concept map of cell structure and macromolecules, plus a one-page written explanation of membrane transport checked against a textbook for accuracy.

Week 2

Cellular and Molecular Biology

  • Trace the inputs and outputs of glycolysis, the Krebs cycle, and oxidative phosphorylation, stating where each occurs in the cell.

  • Calculate the net ATP yield per glucose molecule under aerobic versus anaerobic conditions and identify where the accounting differs.

  • Describe how enzymes lower activation energy and predict the effect of temperature, pH, and a competitive inhibitor on reaction rate.

  • Contrast photosynthesis and cellular respiration in terms of electron carriers, proton gradients, and energy flow.

Your checkpoint

A completed worksheet of 15 self-written questions on bioenergetics with worked answers, including two quantitative ATP-yield problems.

Week 3

Cellular and Molecular Biology & Genetics and Evolution

  • Sequence the stages of mitosis and meiosis and state the chromosome and DNA content at each checkpoint.

  • Explain how crossing over and independent assortment generate genetic variation in gametes.

  • Describe the central dogma and distinguish transcription from translation in terms of location, template, and product.

  • Predict the phenotypic consequence of a specified point mutation (silent, missense, nonsense, frameshift) in a coding sequence.

Your checkpoint

A one-page flowchart from DNA to protein with mutation examples annotated, plus a meiosis-versus-mitosis comparison table.

Week 4

Genetics and Evolution

  • Solve monohybrid and dihybrid crosses using Punnett squares and verify ratios with the product rule.

  • Distinguish complete dominance, incomplete dominance, codominance, and sex-linked inheritance using worked examples.

  • Interpret a pedigree to determine the most likely mode of inheritance and justify the reasoning.

  • Apply Hardy-Weinberg equations to calculate allele and genotype frequencies and identify which assumptions a given scenario violates.

Your checkpoint

A problem set of 20 genetics problems (at least five pedigrees and five Hardy-Weinberg calculations) solved with shown work, scored at 85 percent or higher.

Week 5

Genetics and Evolution

  • Summarize the evidence for evolution from fossils, comparative anatomy, molecular homology, and biogeography.

  • Explain natural selection as a mechanism by distinguishing it from genetic drift, gene flow, and mutation.

  • Describe speciation pathways (allopatric, sympatric) and the role of reproductive isolating mechanisms.

  • Construct a cladogram from a small character matrix and interpret shared derived traits.

Your checkpoint

A written response of roughly 400 words arguing how a specified population could diverge into two species, citing at least three lines of evidence.

Week 6

Organismal Biology and Ecology

  • Compare plant and animal organ systems in terms of transport, gas exchange, and waste removal.

  • Explain how homeostasis is maintained through negative feedback, using at least two physiological examples with sensors and effectors identified.

  • Analyze energy flow and trophic levels in a food web, calculating the approximate energy transferred between levels.

  • Describe population growth models (exponential, logistic) and the factors that produce carrying capacity.

  • Predict how removing a keystone species alters community structure and species richness.

Your checkpoint

A food-web diagram for a named ecosystem with trophic levels labeled and a paragraph predicting the effects of removing one keystone species.

Week 7

Organismal Biology and Ecology & Scientific Inquiry, Pedagogy, and Laboratory Safety

  • Design a controlled experiment on a life science question, specifying independent, dependent, and controlled variables plus a negative control.

  • Evaluate a described experimental setup for sources of bias, confounding variables, and adequacy of sample size.

  • Interpret data presented as a table or graph, identifying trends and stating whether the data support the proposed hypothesis.

  • Write a laboratory safety plan covering chemical handling, biohazard disposal, and emergency procedures for a high school classroom.

Your checkpoint

A complete experimental design document for one investigation, including variables, procedure, safety plan, and a data table template.

Week 8

Scientific Inquiry, Pedagogy, and Laboratory Safety & Cellular and Molecular Biology & Genetics and Evolution & Organismal Biology and Ecology

  • Construct a standards-aligned lesson outline for one life science topic that includes a phenomenon, an investigation, and an assessment check.

  • Create a rubric that scores scientific explanation using claim, evidence, and reasoning.

  • Complete a timed 60-question mixed practice test across all four domains and log every missed item by domain.

  • Re-teach your three weakest concepts from the practice test in short written summaries without notes.

Your checkpoint

A full practice-test score report with a domain-by-domain error log and three written re-teach summaries.

Milestones

Week 2: Explain cellular respiration and membrane transport aloud for five minutes without notes, and score at least 80 percent on a self-made 15-question bioenergetics quiz.

Week 4: Complete the 20-problem genetics set at 85 percent or higher, with pedigree and Hardy-Weinberg items all correct or corrected in writing.

Week 6: Draw a food web from memory, label trophic levels, and explain negative feedback with two physiological examples in under ten minutes.

Week 8: Score at least 75 percent on the mixed 60-question practice test with no single domain below 65 percent, and show the completed error log.