Pathology Technology Series (China) flashcards
Pathology Technology Series (China) · Build recall with a focused review session.
28 cards. Read the term and the definition here. The deck at the top of this page is optional.
- Metaplasia
- Replacement of one differentiated cellular pattern by another in a tissue, distinct from a diagnosis of malignancy.
- Granulation tissue
- Vascular repair tissue containing proliferating vessels and fibroblasts, distinct from a macrophage-rich granulomatous inflammatory pattern.
- Differentiation
- The degree of resemblance of a neoplasm to its normal counterpart, distinct from its extent or stage.
- Artifact
- A preparation- or observation-related feature that can obscure or mimic biology and requires technical-context assessment.
- Cold ischemic interval
- Time before effective preservation during which tissue biology and molecular targets can change, interpreted within the actual specimen pathway.
- Cross-linking fixation
- Preservation involving chemical links between macromolecules that can support morphology while altering access to some targets.
- Decalcification
- Removal of mineral to permit processing and sectioning, with method-dependent effects on morphology and downstream assays.
- Endpoint assessment
- Evaluation of whether a defined processing stage has achieved its purpose without unnecessary continuation and associated damage.
- Clearing
- An intermediate reagent transition between dehydration and infiltration in a compatible conventional paraffin-processing sequence.
- Infiltration
- Introduction of a suitable supporting medium into prepared tissue under the validated processing conditions for sectioning.
- Embedding orientation
- Deliberate positioning of material so the intended diagnostic relationships can be reached and observed in sections.
- Water carryover
- Unwanted retained water transferred into a later reagent stage where it can interfere with clearing or support-medium infiltration.
- Facing
- Initial trimming to expose useful tissue in a block while avoiding unnecessary loss of a small diagnostic focus.
- Chatter
- A sectioning artifact with repeated thick-thin bands that can arise from several tissue or mechanical conditions.
- Score line
- A repeated linear section defect that can be associated with blade damage and needs appropriate technical investigation.
- Wet fixation
- Immediate preservation of a preparation in the suitable liquid fixative when required by the intended cytological method.
- Mordant
- A component of an appropriate dye system that helps form a staining complex with useful tissue affinity.
- Differentiation in staining
- Controlled removal of excess staining to obtain useful contrast, distinct from the biological differentiation of a tumor.
- Digestion control
- A paired preparation that removes a selected substrate to test whether staining depends on that substrate.
- Birefringence
- An optical behavior examined with appropriate polarization that supports selected histochemical interpretations in their full morphological context.
- Antigen retrieval
- A validated treatment intended to improve antibody access to a target affected by tissue preparation or fixation.
- Chromogen
- A reagent system producing a visible reaction product whose localization and solvent compatibility require method-specific interpretation.
- No-template control
- An amplification control without the intended template used to investigate background signal or contamination in the tested system.
- In-situ hybridization
- Detection of selected nucleic-acid sequences within a preparation while retaining their relationship to the examined cells or tissue.
- Internal quality control
- Monitoring intended to detect analytical-system instability during routine work using appropriate materials, limits and investigation rules.
- External quality assessment
- An organized comparison of laboratory performance with suitable external evaluation rather than a complete guarantee for all patient samples.
- Traceability
- The ability to link a specimen and result with relevant collection, method, reagent, equipment, operator and record information.
- Corrective action
- A documented response addressing the cause of a nonconformance and assessing whether the intervention prevented recurrence.