Pathology Technology Series (China) key terms

Replacement of one differentiated cellular pattern by another in a tissue, distinct from a diagnosis of malignancy.

Vascular repair tissue containing proliferating vessels and fibroblasts, distinct from a macrophage-rich granulomatous inflammatory pattern.

The degree of resemblance of a neoplasm to its normal counterpart, distinct from its extent or stage.

A preparation- or observation-related feature that can obscure or mimic biology and requires technical-context assessment.

Time before effective preservation during which tissue biology and molecular targets can change, interpreted within the actual specimen pathway.

Preservation involving chemical links between macromolecules that can support morphology while altering access to some targets.

Removal of mineral to permit processing and sectioning, with method-dependent effects on morphology and downstream assays.

Evaluation of whether a defined processing stage has achieved its purpose without unnecessary continuation and associated damage.

An intermediate reagent transition between dehydration and infiltration in a compatible conventional paraffin-processing sequence.

Introduction of a suitable supporting medium into prepared tissue under the validated processing conditions for sectioning.

Deliberate positioning of material so the intended diagnostic relationships can be reached and observed in sections.

Unwanted retained water transferred into a later reagent stage where it can interfere with clearing or support-medium infiltration.

Initial trimming to expose useful tissue in a block while avoiding unnecessary loss of a small diagnostic focus.

A sectioning artifact with repeated thick-thin bands that can arise from several tissue or mechanical conditions.

A repeated linear section defect that can be associated with blade damage and needs appropriate technical investigation.

Immediate preservation of a preparation in the suitable liquid fixative when required by the intended cytological method.

A component of an appropriate dye system that helps form a staining complex with useful tissue affinity.

Controlled removal of excess staining to obtain useful contrast, distinct from the biological differentiation of a tumor.

A paired preparation that removes a selected substrate to test whether staining depends on that substrate.

An optical behavior examined with appropriate polarization that supports selected histochemical interpretations in their full morphological context.

A validated treatment intended to improve antibody access to a target affected by tissue preparation or fixation.

A reagent system producing a visible reaction product whose localization and solvent compatibility require method-specific interpretation.

An amplification control without the intended template used to investigate background signal or contamination in the tested system.

Detection of selected nucleic-acid sequences within a preparation while retaining their relationship to the examined cells or tissue.

Monitoring intended to detect analytical-system instability during routine work using appropriate materials, limits and investigation rules.

An organized comparison of laboratory performance with suitable external evaluation rather than a complete guarantee for all patient samples.

The ability to link a specimen and result with relevant collection, method, reagent, equipment, operator and record information.

A documented response addressing the cause of a nonconformance and assessing whether the intervention prevented recurrence.