Facharzt FMH Pathologie - independent subject foundations flashcards
Facharzt FMH Pathologie - independent subject foundations · Build recall with a focused review session.
20 cards. Read the term and the definition here. The deck at the top of this page is optional.
- Architecture
- The arrangement and relationship of tissue elements, which can provide diagnostic information not fully represented by dispersed cells.
- Desmoplasia
- A fibrous stromal response interpreted with the lesion and anatomy rather than as independent proof of malignancy.
- Myoepithelial layer
- A supporting cell layer relevant to selected epithelial differentials, assessed with morphology and appropriate marker limitations.
- Lepidic growth
- A pulmonary epithelial growth pattern along existing alveolar structures, which does not alone exclude invasion elsewhere in the lesion.
- Perineural invasion
- Tumor involvement in a nerve-related pathway, interpreted within the relevant anatomical and pathological reporting framework.
- Mismatch-repair immunohistochemistry
- Assessment of relevant nuclear proteins using appropriate controls, with loss patterns contributing to a defined diagnostic or reflex pathway.
- Internal positive control
- Expected staining in suitable non-target elements of the same specimen that helps evaluate the interpretability of a result.
- Basolateral staining
- A membrane-staining pattern whose diagnostic significance depends on the organ, biomarker and applicable assay-scoring framework.
- Equivocal result
- A finding requiring the relevant additional assessment rather than automatic conversion into either a confirmed positive or negative result.
- Cell block
- A preparation that can support morphological and ancillary testing of cytological material, subject to the actual specimen and validation.
- Tumor diathesis
- A cytological background associated with tissue breakdown and possible malignancy that does not independently establish every invasion relationship.
- Clonal population
- A population with evidence of a shared origin, which requires context before it is equated with a specific clinical neoplasm.
- Whole-arm codeletion
- Loss involving the relevant full chromosomal arms, distinguished from partial probe-level events in an integrated classification.
- Break-apart FISH
- A probe strategy for assessing rearrangement at a specified locus, without necessarily identifying the fusion partner.
- Antigen retrieval
- A validated preparatory approach to improve detection of an epitope whose accessibility has been affected by tissue handling.
- Decalcification
- Removal of mineral from tissue through a chosen method that can affect morphology, antigenicity and molecular test performance.
- Clonal hematopoiesis
- Production of blood cells from an acquired clone, potentially contributing variants to plasma assays without proving a solid-tumor origin.
- Sensitivity
- The proportion of genuinely affected cases identified by a defined test within the actual study and reference framework.
- Specificity
- The proportion of genuinely unaffected cases identified as negative by a defined test within the actual reference framework.
- Kappa statistic
- An agreement measure comparing observed concordance with expected chance agreement, with interpretation affected by the sample and categories.